Florida State University College of Medicine, USA.
Euromov, University of Montpellier, USA.
J Psychosom Res. 2023 Nov;174:111487. doi: 10.1016/j.jpsychores.2023.111487. Epub 2023 Sep 6.
This prospective cohort study examines whether purpose in life is associated with markers of immunity and inflammation and tests these markers as mediators between purpose and episodic memory.
Participants from the Venous Blood Study of the Health and Retirement Study reported on their purpose in life, had their blood assayed for markers of immunity and inflammation, and were administered an episodic memory task (N = 8999). Regression analyses tested the association between purpose and each marker. Prospective mediation analyses (N = 6092) tested whether these markers measured in 2016 were mediators between purpose measured in 2012/2014 and episodic memory measured in 2018.
Higher purpose in life was associated with lower neutrophil counts (β = -0.08, p < .001), lower ratio of neutrophils/lymphocytes (β = -0.05, p < .001), and lower systemic immune inflammation index (β = -0.04, p < .001); purpose was unrelated to monocyte, platelet, and lymphocyte counts or the ratio of platelets/lymphocytes (all ns). Purpose was associated negatively with c-reactive protein (β = -0.07, p < .001), Interleukin-6 (β = -0.08, p < .001), Interleukin-10 (β = -0.07, p < .001), Interleukin-1ra (β = -0.08, p < .001), and soluble Tumor Necrosis Factor Receptor 1 (sTNFR1; β = -0.10, p < .001); purpose was unrelated to Transforming Growth Factor beta 1. These associations were largely not moderated by age, sex, race, ethnicity, and education. Lower neutrophils, Interleukin-6, and sTNFR1 were associated prospectively with better episodic memory and mediated the association between purpose and episodic memory.
Purpose in life is associated with markers of immunity and inflammation, some of which are one mechanism in the pathway between purpose and healthier episodic memory.
本前瞻性队列研究旨在探讨生活目的是否与免疫和炎症标志物相关，并检验这些标志物是否为生活目的与情景记忆之间的中介。
来自健康与退休研究静脉血研究的参与者报告了他们的生活目的，对其血液中的免疫和炎症标志物进行了检测，并进行了情景记忆任务（N=8999）。回归分析检验了生活目的与每个标志物之间的关联。前瞻性中介分析（N=6092）检验了 2016 年测量的这些标志物是否在 2012/2014 年测量的生活目的与 2018 年测量的情景记忆之间起中介作用。
更高的生活目的与更低的中性粒细胞计数（β=-0.08，p<0.001）、更低的中性粒细胞/淋巴细胞比值（β=-0.05，p<0.001）和更低的系统性免疫炎症指数（β=-0.04，p<0.001）相关；目的与单核细胞、血小板和淋巴细胞计数或血小板/淋巴细胞比值均不相关（均无统计学意义）。目的与 C 反应蛋白（β=-0.07，p<0.001）、白细胞介素-6（β=-0.08，p<0.001）、白细胞介素-10（β=-0.07，p<0.001）、白细胞介素-1ra（β=-0.08，p<0.001）和可溶性肿瘤坏死因子受体 1（sTNFR1；β=-0.10，p<0.001）呈负相关；目的与转化生长因子β 1 不相关。这些关联在很大程度上不受年龄、性别、种族、民族和教育的调节。较低的中性粒细胞、白细胞介素-6 和 sTNFR1 与更好的情景记忆相关，并介导了生活目的与情景记忆之间的关联。
生活目的与免疫和炎症标志物相关，其中一些标志物是生活目的与更健康的情景记忆之间的关联途径之一。
