调控小鼠快速眼动睡眠：外侧杏仁核中多巴胺和血清素功能的作用。
Regulation of REM sleep in mice: The role of dopamine and serotonin function in the basolateral amygdala.
机构信息
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
出版信息
Neurosci Res. 2024 Mar;200:28-33. doi: 10.1016/j.neures.2023.09.003. Epub 2023 Sep 9.
Animals have a sleep cycle that involves the repetitive occurrence of non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. In a previous study, we discovered that a transient increase in dopamine (DA) levels in the basolateral amygdala (BLA) during NREM sleep terminates NREM sleep and initiates REM sleep by acting on Drd2-positive neurons (Hasegawa et al., 2022). In this study, we identified the neurons activated by the transient increase of DA in the BLA and found that chemogenetic excitation of these neurons increased REM sleep. Additionally, we demonstrated that acute inhibition of serotonin (5HT) in the BLA elicited a transient increase in DA in the BLA, which triggered REM sleep.
动物的睡眠周期包括非快速眼动（NREM）睡眠和快速眼动（REM）睡眠的重复发生。在之前的一项研究中，我们发现，NREM 睡眠期间基底外侧杏仁核（BLA）中多巴胺（DA）水平的短暂增加通过作用于 Drd2 阳性神经元（Hasegawa 等人，2022 年）终止 NREM 睡眠并启动 REM 睡眠。在这项研究中，我们确定了 BLA 中 DA 短暂增加激活的神经元，并发现这些神经元的化学遗传兴奋增加了 REM 睡眠。此外，我们证明了 BLA 中 5-羟色胺（5HT）的急性抑制会引起 BLA 中 DA 的短暂增加，从而引发 REM 睡眠。
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