Hughes W S
Dig Dis Sci. 1986 Nov;31(11):1201-6. doi: 10.1007/BF01296519.
Duodenal gastrin concentration was measured in endoscopic forceps biopsy specimens of the juxta-pyloric duodenal mucosa in patients with various gastrointestinal disorders. Duodenal gastrin concentration was 5.9 +/- 1.2 ng/mg (mean +/- 1 SEM) in control patients. Duodenal gastrin concentration was similar to control values in patients with duodenal ulcer, pyloric channel ulcer, vagotomy and pyloroplasty, and gastric atrophy and hypergastrinemia. In gastric ulcer patients, duodenal gastrin concentration, 2.8 +/- 0.6 ng/mg, was significantly less than the control value (P less than 0.05). Duodenal gastrin concentration was approximately one third of antral gastrin concentration in control, duodenal ulcer, and gastric ulcer patients and was approximately one fifth of antral gastrin concentration in vagotomy and pyloroplasty patients and gastric atrophy patients. Duodenal and antral gastrin concentrations were significantly correlated in normal controls and in gastric ulcer patients. The finding of normal duodenal gastrin concentration in patients with vagotomy and pyloroplasty and patients with gastric atrophy suggests that, unlike antral gastrin concentration, duodenal gastrin concentration is unaffected by a decrease in acid secretion rate. The low duodenal gastrin concentration in gastric ulcer patients indicates that the duodenum may be involved in the pathophysiology of gastric ulcer disease.
在患有各种胃肠道疾病的患者中，通过内镜钳取胃幽门部十二指肠黏膜活检标本，测定十二指肠胃泌素浓度。对照组患者的十二指肠胃泌素浓度为5.9±1.2 ng/mg（平均值±1个标准误）。十二指肠溃疡、幽门管溃疡、迷走神经切断术加幽门成形术、胃萎缩及高胃泌素血症患者的十二指肠胃泌素浓度与对照组值相似。胃溃疡患者的十二指肠胃泌素浓度为2.8±0.6 ng/mg，显著低于对照组值（P<0.05）。在对照组、十二指肠溃疡患者和胃溃疡患者中，十二指肠胃泌素浓度约为胃窦胃泌素浓度的三分之一；在迷走神经切断术加幽门成形术患者和胃萎缩患者中，十二指肠胃泌素浓度约为胃窦胃泌素浓度的五分之一。在正常对照组和胃溃疡患者中，十二指肠和胃窦胃泌素浓度显著相关。迷走神经切断术加幽门成形术患者和胃萎缩患者十二指肠胃泌素浓度正常这一发现表明，与胃窦胃泌素浓度不同，十二指肠胃泌素浓度不受胃酸分泌率降低的影响。胃溃疡患者十二指肠胃泌素浓度较低，表明十二指肠可能参与了胃溃疡疾病的病理生理过程。
