Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nat Rev Immunol. 2024 Feb;24(2):142-155. doi: 10.1038/s41577-023-00932-3. Epub 2023 Sep 11.
Cryptosporidium parasites replicate within intestinal epithelial cells and are an important cause of diarrhoeal disease in young children and in patients with primary and acquired defects in T cell function. This Review of immune-mediated control of Cryptosporidium highlights advances in understanding how intestinal epithelial cells detect this infection, the induction of innate resistance and the processes required for activation of T cell responses that promote parasite control. The development of a genetic tool set to modify Cryptosporidium combined with tractable mouse models provide new opportunities to understand the principles that govern the interface between intestinal epithelial cells and the immune system that mediate resistance to enteric pathogens.
隐孢子虫寄生虫在肠道上皮细胞内复制，是导致幼儿和 T 细胞功能原发性和获得性缺陷患者腹泻病的重要原因。本综述重点介绍了对隐孢子虫免疫介导控制的研究进展，包括肠道上皮细胞如何检测这种感染、先天抵抗的诱导以及激活促进寄生虫控制的 T 细胞反应所需的过程。遗传工具的开发可用于修饰隐孢子虫，再结合可操作的小鼠模型，为理解肠道上皮细胞与免疫系统之间的相互作用提供了新的机会，这些相互作用介导了对肠道病原体的抵抗。
