Cryptosporidiosis Laboratory, The Francis Crick Institute, London, United Kingdom.
Front Cell Infect Microbiol. 2020 Nov 18;10:587296. doi: 10.3389/fcimb.2020.587296. eCollection 2020.
Cryptosporidiosis is a leading cause of diarrheal disease and an important contributor to global morbidity and mortality. Although the brunt of disease burden is felt by children in developing countries, is a ubiquitous intestinal parasite with frequent outbreaks around the world. There are no consistently effective treatments for cryptosporidiosis and the research to drive new developments has stagnated, largely due to a lack of efficient and models. Fortunately, these research barriers have started to fall. In this review, we highlight two recent advances aiding this process: A tractable mouse model for infection and stem cell-based culture systems that mimic the complexity of the host intestine. These models are paving the way for researchers to investigate infection and host immunity down to a molecular level. We believe that wise investments made to adopt and develop these new models will reap benefits not only for the community but also for the intestinal immunology field at large.
隐孢子虫病是腹泻病的主要病因，也是全球发病率和死亡率的重要因素。尽管发展中国家的儿童是疾病负担的主要人群，但 是一种无处不在的肠道寄生虫，在世界各地经常爆发。目前还没有针对隐孢子虫病的有效治疗方法，推动新发展的研究已经停滞不前，主要是因为缺乏有效的 和 模型。幸运的是，这些研究障碍开始被打破。在这篇综述中，我们强调了两个最近的进展，它们有助于推动这一进程：一种用于 感染的可处理的小鼠模型和模拟宿主肠道复杂性的基于干细胞的 培养系统。这些模型为研究人员提供了一条途径，可在分子水平上研究 感染和宿主免疫。我们相信，明智地投资于采用和开发这些新模型不仅将使 界受益，也将使整个肠道免疫学领域受益。
