Department of Radiology and Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman.
Department of Radiology, Stony Brook University, New York USA.
J Pak Med Assoc. 2023 Aug;73(8):1744-1746. doi: 10.47391/JPMA.23-59.
Primary central nervous system lymphoma (PCNSL) is a rare but highly aggressive lymphoma with increasing incidence in immunocompromised patients. MRI is the modality of choice in evaluating brain lesions. However, MRI is often challenging in the detection of early recurrence, assessing residual disease and response evaluation in PCNSL. 18F-FDG PET/CT has superior diagnostic performance compared with body CT in the evaluation of lymphoma. 18F-FDG PET-CT is helpful in evaluating evaluation of disease extent and differentiating primary CNS lymphoma from systemic lymphoma. Besides diagnostic and prognostic value in primary CNS lymphoma, it might also be helpful in response assessment. The role of FDG-PET in PCNSL is not fully defined. In this article we have reviewed the potential role of 18F-FDG PET/CT in initial diagnosis, baseline staging, restaging, evaluation of treatment response, prognostication, and survival analysis of PCNSL.
原发性中枢神经系统淋巴瘤（PCNSL）是一种罕见但侵袭性很强的淋巴瘤，在免疫功能低下的患者中发病率不断增加。磁共振成像（MRI）是评估脑部病变的首选方式。然而，MRI 常常难以检测早期复发，评估 PCNSL 的残留疾病和反应。与全身 CT 相比，18F-FDG PET/CT 在评估淋巴瘤方面具有更好的诊断性能。18F-FDG PET-CT 有助于评估疾病范围，并将原发性中枢神经系统淋巴瘤与系统性淋巴瘤区分开来。除了在原发性中枢神经系统淋巴瘤中的诊断和预后价值外，它在反应评估中也可能有帮助。18F-FDG-PET 在 PCNSL 中的作用尚未完全确定。本文综述了 18F-FDG PET/CT 在 PCNSL 的初始诊断、基线分期、再分期、治疗反应评估、预后和生存分析中的潜在作用。
