评估口腔各亚部位的浸润深度，作为美国癌症联合委员会（AJCC）第8版口腔鳞状细胞癌T分期标准的一部分。
Evaluating depth of invasion across oral cavity subsites as part of the AJCC 8th edition T staging criteria for oral cavity squamous cell carcinoma.
作者信息
Gilja Shivee, Barlow Joshua, Kumar Arvind, Berger Michael H, Khan Mohemmed N, Kirke Diana N, Roof Scott A
机构信息
Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
出版信息
Head Neck. 2023 Nov;45(11):2780-2788. doi: 10.1002/hed.27497. Epub 2023 Sep 12.
BACKGROUND
The prognostic impact of depth of invasion (DOI) in American Joint Committee on Cancer 8th edition TNM staging for oral cavity squamous cell carcinoma (OCSCCa) across oral cavity subsites is unknown.
METHODS
Overall survival of patients with pT1-4a OCSCCa in the National Cancer Database (2010-2017), stratified by tumor size and DOI across eight oral cavity subsites, was evaluated using multivariable-adjusted Cox proportional hazards modeling.
RESULTS
When stratified by tumor size ≤2 cm and >2 cm, DOI >5 mm and DOI >10 mm were only associated with worse overall survival, respectively, for tumors of the oral tongue (Tumor size ≤2 cm, DOI >5 mm v DOI ≤5 mm: HR: 1.31, 95% CI: 1.12-1.53, p < 0.001; Tumor size >2 cm, DOI >10 mm v DOI ≤10 mm: HR: 1.15, 95% CI: 1.01-1.30, p = 0.03). DOI >5 mm and DOI >10 mm was not prognostic for any other tumor location.
CONCLUSIONS
These findings suggest that the current staging schema for DOI in OCSCCa may not be prognostic across all oral cavity subsites.
背景
美国癌症联合委员会第8版TNM分期中，口腔鳞状细胞癌（OCSCCa）侵犯深度（DOI）对口腔各亚部位的预后影响尚不清楚。
方法
利用多变量调整的Cox比例风险模型，评估了国家癌症数据库（2010 - 2017年）中pT1 - 4a期OCSCCa患者的总生存期，该生存期按肿瘤大小和八个口腔亚部位的DOI进行分层。
结果
按肿瘤大小≤2 cm和>2 cm分层时，DOI>5 mm和DOI>10 mm仅分别与舌部肿瘤的较差总生存期相关（肿瘤大小≤2 cm，DOI>5 mm与DOI≤5 mm相比：HR：1.31，95% CI：1.12 - 1.53，p<0.001；肿瘤大小>2 cm，DOI>10 mm与DOI≤10 mm相比：HR：1.15，95% CI：1.01 - 1.30，p = 0.03）。DOI>5 mm和DOI>10 mm对任何其他肿瘤部位均无预后价值。
结论
这些发现表明，目前OCSCCa中DOI的分期方案可能并非对所有口腔亚部位都具有预后价值。
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