Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai, 200444, China.
Weihai Medical Area, 970 Hospital of Joint Logistic Support Force of PLA, Weihai, 264200, China.
Adv Sci (Weinh). 2023 Oct;10(29):e2302918. doi: 10.1002/advs.202302918. Epub 2023 Sep 12.
Atherosclerosis, the leading cause of death worldwide, is responsible for ≈17.6 million deaths globally each year. Most therapeutic drugs for atherosclerosis have low delivery efficiencies and significant side effects, and this has hampered the development of effective treatment strategies. Diversified nanomaterials can improve drug properties and are considered to be key for the development of improved treatment strategies for atherosclerosis. The pathological mechanisms underlying atherosclerosis is summarized, rationally designed nanoparticle-mediated therapeutic strategies, and potential future therapeutic targets for nanodelivery. The content of this study reveals the potential and challenges of nanoparticle use for the treatment of atherosclerosis and highlights new effective design ideas.
动脉粥样硬化是全球范围内主要的致死原因，每年导致全球约 1760 万人死亡。大多数动脉粥样硬化的治疗药物递送效率低，且副作用明显，这阻碍了有效治疗策略的发展。多样化的纳米材料可以改善药物特性，被认为是开发动脉粥样硬化改良治疗策略的关键。本文总结了动脉粥样硬化的病理机制，合理设计了纳米颗粒介导的治疗策略，以及纳米递药的潜在未来治疗靶点。本研究内容揭示了纳米颗粒治疗动脉粥样硬化的潜力和挑战，突出了新的有效设计思路。
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