使用磺酰肼通过铜催化实现酮的直接硫醇化：一种合成苄基硫醚的途径。
Copper-Catalyzed Direct Thiolation of Ketones Using Sulfonohydrazides: A Synthetic Route to Benzylic Thioethers.
作者信息
Jadhao Amardeep Ramprasad, Gaikwad Sanjay Subhash
机构信息
Department of Chemistry, Late Pushpadevi Patil Arts & Science College Risod, Dist-Washim, Washim, Maharashtra 444506, India.
Department of Chemistry, MES, Abasaheb Garware College, Pune, Maharashtra 411004, India.
出版信息
J Org Chem. 2023 Oct 6;88(19):14078-14087. doi: 10.1021/acs.joc.3c01598. Epub 2023 Sep 12.
A facile copper-catalyzed sustainable thiolation of ketones with sulfonohydrazides has been designed for the efficient construction of benzylic thioethers in excellent yield under mild reaction conditions. The current approach avoids the widely used thiolation reagent, thiols. The commercial availability of the base and reagents, broad substrate scope, and convenient reaction procedure make it an attractive method for benzylic thioether synthesis.
已设计出一种简便的铜催化的酮与磺酰肼的可持续硫醇化反应，用于在温和的反应条件下以优异的产率高效构建苄基硫醚。目前的方法避免了广泛使用的硫醇化试剂——硫醇。碱和试剂的商业可得性、广泛的底物范围以及简便的反应程序使其成为一种有吸引力的苄基硫醚合成方法。
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