Departments of Radiation Oncology.
Departments of Pediatric Hematology and Oncology.
J Pediatr Hematol Oncol. 2023 Nov 1;45(8):e1005-e1009. doi: 10.1097/MPH.0000000000002754. Epub 2023 Sep 13.
Pleomorphic xanthoastrocytoma (PXA) is a rare type of grade 2 or 3 brain tumor that usually occurs in children and young adults. The standard treatment for PXA is maximally safe resection, usually with adjuvant radiation therapy, for high-grade tumors. BRAF V600E mutation is one of the most common molecular alterations in these tumors, with nearly 70% of cases carrying this mutation. Although BRAF inhibitors have shown promise in treating progressive or refractory disease, their use has been associated with various adverse effects, including radiodermatitis, which is a relatively common complication. This paper presents a case of a 16-year-old male patient with BRAF-mutated metastatic PXA, who developed mild radiodermatitis after receiving BRAF inhibitors with concurrent radiation therapy.
多形性黄色星形细胞瘤（PXA）是一种罕见的 2 级或 3 级脑肿瘤，通常发生在儿童和青年。PXA 的标准治疗方法是最大限度地安全切除，对于高级别肿瘤，通常还需要辅助放射治疗。BRAF V600E 突变是这些肿瘤中最常见的分子改变之一，近 70%的病例携带这种突变。尽管 BRAF 抑制剂在治疗进展或难治性疾病方面显示出了一定的疗效，但它们的使用与各种不良反应有关，包括放射性皮炎，这是一种相对常见的并发症。本文介绍了一例 16 岁男性 BRAF 突变转移性 PXA 患者，在接受 BRAF 抑制剂联合放射治疗后出现轻度放射性皮炎。
