Berneman Z N, Gastl G, Gangji D, van Camp B, Jochmans K, Aulitzky W, Flament J, Peetermans M E, Huber C
Eur J Cancer Clin Oncol. 1986 Aug;22(8):987-90. doi: 10.1016/0277-5379(86)90066-0.
Eleven patients with hairy-cell leukemia (eight with progressive and three with non-progressive disease) were treated with low dose recombinant human alpha 2-interferon. After a 3-month treatment period, nine patients showed an improvement and one patient a partial remission. By then, transfusions were not required any more and serious infections were no longer encountered. Four patients were further treated: three for a total period of 9 months and one for 6 months; all of them reached a partial or complete remission. The treatment was equally effective in patients with both progressive and non-progressive disease. Previous absence of response to splenectomy did not preclude a positive effect of IFN therapy. In two patients, IFN dose reduction was necessary due to unremitting flu-like symptoms.
11例毛细胞白血病患者（8例为进展期，3例为非进展期）接受了低剂量重组人α2干扰素治疗。经过3个月的治疗期后，9例患者病情改善，1例患者部分缓解。此时，不再需要输血，也未再发生严重感染。4例患者继续接受治疗：3例共治疗9个月，1例治疗6个月；所有患者均达到部分或完全缓解。该治疗对进展期和非进展期患者均同样有效。既往对脾切除术无反应并不排除干扰素治疗产生阳性效果。2例患者因持续存在流感样症状而需要减少干扰素剂量。
