Baaklini Carla, Kesav Natasha, Reinhart William
Ophthalmology, University of Missouri, Columbia, USA.
Ophthalmology, University Hospitals Cleveland Medical Center, Cleveland, USA.
Cureus. 2023 Aug 10;15(8):e43307. doi: 10.7759/cureus.43307. eCollection 2023 Aug.
We report a case of minocycline-induced ocular ochronosis with scleral, retinal, and cutaneous manifestations. A 65-year-old male who had taken minocycline for four years to treat hidradenitis suppurativa, an inflammatory skin condition affecting the apocrine sweat glands and hair follicles, presented for evaluation of discoloration of bilateral sclera, nail beds, and gingiva. Ophthalmic evaluation revealed intact visual acuity, diffuse blue-gray hyperpigmentation of the sclera, more pronounced overlying insertions of the horizontal muscles, without any scleral thinning. Macular optical coherence tomography and fundus exam revealed a blue hue to the underlying choroid with dark deposits in the retinal pigment epithelium. Despite drug discontinuation, after six years the discoloration persisted. Management was directed towards patient tolerability.
我们报告一例米诺环素诱导的眼皮肤异色病，伴有巩膜、视网膜和皮肤表现。一名65岁男性，因治疗化脓性汗腺炎（一种影响顶泌汗腺和毛囊的炎症性皮肤病）服用米诺环素四年，前来评估双侧巩膜、甲床和牙龈变色情况。眼科评估显示视力正常，巩膜弥漫性蓝灰色色素沉着，在水平肌附着处更为明显，无巩膜变薄。黄斑光学相干断层扫描和眼底检查显示脉络膜呈蓝色调，视网膜色素上皮有深色沉积物。尽管停药，但六年后色素沉着仍持续存在。治疗以患者耐受性为导向。
