Rangaswamaiah Hareesh, Somashekar Pallavi, Gutlur Nagarajaiah Setty Raghav, Ganesh Veluri
Department of General Medicine, Akash Institute of Medical Sciences and Research Centre, Bangalore - 562110, Karnataka, India.
Department of General Medicine, Rajarajeswari Medical College and Hospital, Bangalore - 560074, Karnataka, India.
Bioinformation. 2022 Dec 31;18(12):1131-1135. doi: 10.6026/973206300181131. eCollection 2022.
Diabetic nephropathy is a one of the risk factor for end stage renal disease in patients with type 2 diabetes mellitus. Urinary micr oalbumin currently marker using for diagnosis of nephropathy in type 2 diabetes mellitus due to its larger variability and less specificity. Urinary nephrin is podocyte protein can be act as a early predictable and prognostic marker than micro albumin for nephropathy in type 2 diabetes mellitus. This case-control prospective observational study included 60 type 2 diabetes mellitus and 30 controls after applying criteria. Basic biochemical, clinical and experimental data were measured and recorded. There was a significantly elevated level of urinary nephrin in type 2 diabetes mellitus patients when compared to controls. The urinary nephrin significantly elevated in normo albuminuria group only when compared to urinary ACR and it is positive association with kidney damage. This study concluded significantly elevated levels of urinary nephrin might be used for early diagnosis and prognostic marker for nephropathy in type 2 diabetes mellitus.
糖尿病肾病是2型糖尿病患者终末期肾病的危险因素之一。由于尿微量白蛋白变异性较大且特异性较低，目前它是用于诊断2型糖尿病肾病的标志物。尿nephrin是一种足细胞蛋白，对于2型糖尿病肾病而言，它可作为比微量白蛋白更早的预测和预后标志物。这项病例对照前瞻性观察研究纳入了60例2型糖尿病患者和30例符合标准后的对照。测量并记录了基本生化、临床和实验数据。与对照组相比，2型糖尿病患者的尿nephrin水平显著升高。仅与尿ACR相比时，正常白蛋白尿组的尿nephrin显著升高，且它与肾损伤呈正相关。本研究得出结论，尿nephrin水平显著升高可能用于2型糖尿病肾病的早期诊断和预后标志物。
