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[强心苷与患者红细胞的结合]

[Binding of cardiac glycosides by the erythrocytes of patients].

作者信息

Bakaev V V

出版信息

Farmakol Toksikol. 1986 Sep-Oct;49(5):25-7.

PMID:3770168
Abstract

Digoxin and strophanthin K uptake by patients' red cells was investigated by the Rb-86 assay. It was found that digoxin and strophanthin K levels in red cells increased with augmentation of the drugs concentrations in plasma, the ratio of cardiac glycoside levels in red cells to their concentrations in plasma decreased. The degree of binding to red cells is more pronounced for strophanthin K than for digoxin.

摘要

通过铷-86测定法研究了患者红细胞对洋地黄毒苷和毒毛花苷K的摄取。发现红细胞中的洋地黄毒苷和毒毛花苷K水平随着血浆中药物浓度的增加而升高,红细胞中心脏糖苷水平与其血浆浓度的比值降低。毒毛花苷K与红细胞的结合程度比洋地黄毒苷更明显。

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