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[肺结核患者中乙胺丁醇的药代动力学]

[Ethambutol pharmacokinetics in pulmonary tuberculosis patients].

作者信息

Sokolova G B, Ziia A V, Abramovich A G, Bessarabova T N, Ivleva A Ia

出版信息

Farmakol Toksikol. 1986 Sep-Oct;49(5):40-2.

PMID:3770174
Abstract

Specific features of ethambutol pharmacokinetics were studied in 53 patients with first detected pulmonary tuberculosis. Pharmacokinetic parameters were interpreted by using an one-part model with absorption. Pharmacokinetic parameters Cmax, Me infinity were shown to be distributed according to a normal law of distribution of probabilities, Kel--according to a logarithmically normal law.

摘要

对53例初诊肺结核患者的乙胺丁醇药代动力学的特定特征进行了研究。采用具有吸收的单室模型解释药代动力学参数。药代动力学参数Cmax、Me无穷大呈概率正态分布,Kel呈对数正态分布。

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