Grignoli Nicola, Petrocchi Serena, Polito Andrea, Gagliano Vanessa, Sallusto Federica, Uguccioni Mariagrazia, Gabutti Luca
Department of Internal Medicine, Regional Hospital of Bellinzona and Valleys, Ente Ospedaliero Cantonale, Bellinzona and Università della Svizzera italiana, Lugano, Switzerland.
Cantonal Sociopsychiatric Organisation, Public Health Division, Department of Health and Social Care, Repubblica e Cantone Ticino, Mendrisio, Switzerland.
Brain Behav Immun Health. 2023 Aug 25;33:100677. doi: 10.1016/j.bbih.2023.100677. eCollection 2023 Nov.
Increasing evidence has been pointing towards the existence of a bi-directional interplay between mental health condition and immunity. Data collected during the COVID-19 outbreak suggest that depressive symptoms may impact the production of antibodies against SARS-CoV-2, while a previous infection could affect the immune response and cause neuropsychological disturbances. A prospective observational study was designed to investigate the association between mental health conditions and immune response over time. We analyzed the mental health at baseline and the antibodies before and after immunization with the COVID-19 mRNA vaccine in a cohort of healthcare professionals in southern Switzerland. One-hundred and six subjects were enrolled. Anxiety, distress and depression correlated to each other. There were no correlations between the mentioned variables and the vaccine induced IgG antibodies against the receptor binding domain (RBD) of the spike protein. For those who had a previous COVID-19 infection, the antibodies increased according to the grade of depression. For those who did not, the anti-RBD IgG levels remained similar when comparing presence or absence of depression symptoms. Our results show that previous SARS-CoV-2 natural infection in subjects with mental health conditions enhances the immune response to COVID-19 mRNA vaccination. The correlation between immune response to COVID-19 vaccination, a previous exposure to the virus, and symptoms of mood disorders, makes it necessary to explore the direction of the causality between immune response and depressive symptoms.
越来越多的证据表明，心理健康状况与免疫力之间存在双向相互作用。在新冠疫情期间收集的数据表明，抑郁症状可能会影响针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的抗体产生，而先前的感染可能会影响免疫反应并导致神经心理障碍。一项前瞻性观察性研究旨在调查心理健康状况与免疫反应随时间的关联。我们分析了瑞士南部一组医护人员在基线时的心理健康状况以及接种新冠信使核糖核酸（mRNA）疫苗前后的抗体情况。共招募了106名受试者。焦虑、痛苦和抑郁相互关联。上述变量与疫苗诱导的针对刺突蛋白受体结合域（RBD）的免疫球蛋白G（IgG）抗体之间没有相关性。对于那些曾感染过新冠病毒的人，抗体水平根据抑郁程度而增加。对于那些没有感染过的人，比较有无抑郁症状时，抗RBD IgG水平保持相似。我们的结果表明，心理健康状况的受试者先前感染SARS-CoV-2会增强对新冠mRNA疫苗的免疫反应。对新冠疫苗接种的免疫反应、先前接触病毒与情绪障碍症状之间的相关性，使得有必要探索免疫反应与抑郁症状之间因果关系的方向。
