Harmar A J, Armstrong A, Pascall J C, Chapman K, Rosie R, Curtis A, Going J, Edwards C R, Fink G
FEBS Lett. 1986 Nov 10;208(1):67-72. doi: 10.1016/0014-5793(86)81534-4.
The nucleotide sequence of cDNA encoding the human substance P precursor, beta-preprotachykinin (beta-PPT), has been determined. The source of mRNA was a human laryngeal carcinoid tumour that contained a high concentration of immunoreactive substance P. The human beta-PPT polypeptide is 129 amino acids long and contains regions encoding substance P and neurokinin A, each flanked by basic amino acid residues. Residues 72-107 of the human beta-PPT polypeptide encode the sequence of neuropeptide K, an N-terminally extended form of neurokinin A recently isolated from porcine brain.
