载有醋酸泼尼松龙的聚合物胶束凝胶用于眼部炎症：研发与评价
Polymeric micelles loaded gel with prednisolone acetate for ocular inflammation: development and evaluation.
作者信息
Kaushal Nikita, Kumar Manish, Tiwari Abhishek, Tiwari Varsha, Sharma Kamini, Sharma Ajay, Marisetti Arya Lakshmi, Gupta Madan Mohan, Kazmi Imran, Alzarea Sami I, Almalki Waleed Hassan, Gupta Gaurav
机构信息
M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, 133207, Haryana.
School of Pharmaceutical Sciences, CT University, Ludhiana, Punjab, 142024, India.
出版信息
Nanomedicine (Lond). 2023 Aug;18(20):1383-1398. doi: 10.2217/nnm-2023-0123. Epub 2023 Sep 13.
Our study developed a prednisolone acetate polymeric micelles (PM) system for ocular inflammation related to allergic uveitis. For PM development, a thin-film hydration procedure was used. Irritation, , transcorneal permeation, micelle size, entrapment efficiency and histology within the eye were all calculated for PM. The optimized gel (A4) showed superior transcorneal permeation with zero-order kinetics. The developed formulation could be a promising candidate for treating anterior uveitis via topical application to the anterior segment of the eye.
我们的研究开发了一种用于与过敏性葡萄膜炎相关的眼部炎症的醋酸泼尼松龙聚合物胶束（PM）系统。对于PM的开发，采用了薄膜水化法。对PM进行了刺激性、经角膜渗透、胶束大小、包封率以及眼内组织学等方面的计算。优化后的凝胶（A4）显示出具有零级动力学的优异经角膜渗透性。所开发的制剂可能是一种通过局部应用于眼前节来治疗前葡萄膜炎的有前景的候选药物。
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