Knudsen G M, Jakobsen J, Juhler M, Paulson O B
Diabetes. 1986 Dec;35(12):1371-3. doi: 10.2337/diab.35.12.1371.
Blood-brain barrier (BBB) permeability to 24Na+, 36Cl-, and [3H]sucrose was studied in rats after 2 wk of streptozocin-induced diabetes. The PS (permeability-surface area product) for Na+ in the cortex of the frontal lobes was 5.4 +/- 0.6 (10(-5) cm3 X g-1 X s-1; +/- SD) in diabetic rats compared with 7.1 +/- 1.7 in control rats. In the occipital cortex, the values were 7.6 +/- 1.5 and 9.9 +/- 1.6, respectively. In contrast, BBB permeability to Cl- and sucrose remained unchanged. We conclude that a selective alteration in BBB permeability to Na+ unrelated to changes in brain capillary surface area is present in experimental diabetes.
在链脲佐菌素诱导的糖尿病大鼠模型中，观察了糖尿病2周后血脑屏障（BBB）对24Na +、36Cl -和[3H]蔗糖的通透性变化。结果发现，糖尿病大鼠额叶皮质中Na +的通透系数（PS，即通透性-表面积乘积）为5.4±0.6（10-5cm3·g-1·s-1；±标准差），而对照大鼠为7.1±1.7。在枕叶皮质中，相应数值分别为7.6±1.5和9.9±1.6。相反，BBB对Cl -和蔗糖的通透性则无明显改变。我们得出结论，实验性糖尿病中存在血脑屏障对Na +通透性的选择性改变，且该改变与脑毛细血管表面积的变化无关。
