Warren Alpert Medical School of Brown University, Providence, Rhode Island; Arthur S. Keats Division of Pediatric Cardiovascular Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
Department of Pediatric Critical Care Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
Ann Thorac Surg. 2024 Apr;117(4):813-819. doi: 10.1016/j.athoracsur.2023.09.003. Epub 2023 Sep 12.
Postoperative cardiac arrest (CA) with or without need for extracorporeal cardiopulmonary resuscitation (ECPR) is one of the most significant complications in the early postoperative period after pediatric cardiac operation. The objective of this study was to develop and to validate a predictive model of postoperative CA with or without ECPR.
In this retrospective cohort study, we reviewed data from patients who underwent cardiac surgery with cardiopulmonary bypass (CPB) between July 20, 2020, and December 31, 2021. Variables included demographic data, presence of preoperative risk factors, The Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery mortality categories, perioperative data, residual lesion score (RLS), and vasoactive-inotropic score (VIS). We used multivariable logistic regression analysis to develop a predictive model.
The incidence of CA with or without ECPR was 4.4% (n = 24/544). Patients who experienced postoperative CA with or without ECPR were younger (age, 130 [54-816.5] days vs 626 [127.5-2497.5] days; P < .050) and required longer CPB (253 [154-332.5] minutes vs 130 [87-186] minutes; P < .010) and cross-clamp (116.5 [75.5-143.5] minutes vs 64 [30-111] minutes; P < .020) times; 37.5% of patients with an outcome had at least 1 preoperative risk factor (vs 16.9%; P < .010). Our multivariable logistic regression determined that the presence of at least 1 preoperative risk factor (P = .005), CPB duration (P = .003), intraoperative residual lesion score (P = .009), and postsurgery vasoactive-inotropic score (P = .010) were predictors of the incidence of CA with or without ECPR.
We developed a predictive model of postoperative CA with or without ECPR after congenital cardiac operation. Our model performed better than the individual scores and risk factors.
小儿心脏手术后,无论是否需要体外心肺复苏(ECPR),术后心脏骤停(CA)都是术后早期最严重的并发症之一。本研究旨在建立和验证一个预测小儿心脏手术后伴有或不伴有 ECPR 的术后 CA 的模型。
本回顾性队列研究回顾了 2020 年 7 月 20 日至 2021 年 12 月 31 日期间接受体外循环(CPB)心脏手术的患者数据。变量包括人口统计学数据、术前危险因素、胸外科医师协会-欧洲心胸外科协会死亡率类别、围手术期数据、残余病变评分(RLS)和血管活性-正性肌力评分(VIS)。我们使用多变量逻辑回归分析来建立预测模型。
伴有或不伴有 ECPR 的 CA 的发生率为 4.4%(n=24/544)。经历术后伴有或不伴有 ECPR 的 CA 的患者年龄更小(年龄,130[54-816.5]天 vs 626[127.5-2497.5]天;P<.050),CPB 时间更长(253[154-332.5]分钟 vs 130[87-186]分钟;P<.010)和体外循环时间(116.5[75.5-143.5]分钟 vs 64[30-111]分钟;P<.020);37.5%的结局患者至少有 1 项术前危险因素(vs 16.9%;P<.010)。我们的多变量逻辑回归确定,至少有 1 项术前危险因素(P=.005)、CPB 时间(P=.003)、术中残余病变评分(P=.009)和术后血管活性-正性肌力评分(P=.010)是伴有或不伴有 ECPR 的术后 CA 发生率的预测因素。
我们建立了一个预测小儿心脏手术后伴有或不伴有 ECPR 的术后 CA 的模型。我们的模型比单个评分和危险因素的预测效果更好。