血清钠与脓毒症患者 28 天死亡率的关系：来自三个大型危重病队列的二次数据分析。
Association between serum sodium and 28-day mortality in sepsis patients: A secondary data analysis from three large critical illness cohorts.
机构信息
Department of Critical Care Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Department of Research, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
出版信息
Ther Apher Dial. 2024 Feb;28(1):96-102. doi: 10.1111/1744-9987.14066. Epub 2023 Sep 13.
OBJECTIVE
The present study was designed to explore the association between serum sodium and mortality in patients with sepsis by using a large sample, multicenter MIMIC-IV database.
METHODS
We extracted the data of 34 925 sepsis patients from the retrospective cohort mimicIV database. After adjusting the confounders, we explored the independent effects of serum sodium on 28-day mortality.
RESULTS
A nonlinear relationship existed between serum sodium and 28-day mortality, of which a negative association was found between serum sodium and 28-day mortality (odds ratio: 0.95, 95% CI: 0.94, 0.96, p = 0.0001) when serum sodium was in 102 mmol/L to 138 mmol/L, but a positive correlation appeared when sodium climbed to the range of 140-179 mmol/L (odds ratio: 1.04, 95% CI: 1.03-1.06, p = 0.0001).
CONCLUSIONS
Both lower and higher serum sodium levels are associated with an increased risk of death in sepsis patients.
目的
本研究旨在利用大型多中心 MIMIC-IV 数据库探讨血清钠与脓毒症患者死亡率之间的关系。
方法
我们从回顾性队列 mimicIV 数据库中提取了 34925 例脓毒症患者的数据。在调整混杂因素后，我们探讨了血清钠对 28 天死亡率的独立影响。
结果
血清钠与 28 天死亡率之间存在非线性关系，当血清钠在 102mmol/L 至 138mmol/L 时，血清钠与 28 天死亡率呈负相关（比值比：0.95，95%可信区间：0.94，0.96，p=0.0001），但当钠攀升至 140-179mmol/L 范围时，呈正相关（比值比：1.04，95%可信区间：1.03，1.06，p=0.0001）。
结论
低血清钠和高血清钠水平均与脓毒症患者死亡风险增加相关。
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