一些局部麻醉药的结构/神经膜效应关系
Structure/nerve membrane effect relationships of some local anaesthetics.
作者信息
Tripşa M, Sahini V E, Nae C, Vasilescu V
出版信息
Gen Physiol Biophys. 1986 Aug;5(4):371-6.
PMID:3770458
Abstract
Data on electron structure and octanol-water partition coefficients of certain local anaesthetics are compared with the capacity of reversibly block the action potential of the frog sciatic nerve. Some active parts in the molecules of these substances have been shown to be primarily involved in the action of local anaesthetics.
摘要
将某些局部麻醉剂的电子结构和正辛醇 - 水分配系数的数据与可逆阻断青蛙坐骨神经动作电位的能力进行了比较。已表明这些物质分子中的一些活性部分主要参与局部麻醉剂的作用。
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