早老样供体培养的真皮成纤维细胞中的细胞膜转运酶：与其他人类成纤维细胞的比较
Cell membrane transport enzymes in cultured dermal fibroblasts from progeroid donors: a comparison to other human fibroblasts.
作者信息
Mokrasch L C
出版信息
Gerontology. 1986;32(4):202-6. doi: 10.1159/000212790.
PMID:3770489
Abstract
Cell membranes from progeroid fibroblasts had an elevated Na+, K+ ATPase. Ca++ ATPase and gamma-glutamyl transpeptidase were markedly decreased in progeroid fibroblast membranes. 5'-nucleotide phosphatase was unchanged, compared to age- and sex-matched normal fibroblast membranes. Fetal lung fibroblasts and dermal fibroblast from myotonic dystrophy victims had enzyme activities similar to those of the normal dermal fibroblasts.
摘要
早衰样成纤维细胞的细胞膜具有升高的钠钾ATP酶。早衰样成纤维细胞膜中的钙ATP酶和γ-谷氨酰转肽酶显著降低。与年龄和性别匹配的正常成纤维细胞膜相比，5'-核苷酸磷酸酶没有变化。来自强直性肌营养不良患者的胎儿肺成纤维细胞和皮肤成纤维细胞的酶活性与正常皮肤成纤维细胞相似。
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