Han Zexiang, Ali Wajid, Mao Ting, Wang Fei, Wang Xiaoli
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology Beijing 100190 P. R. China
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences Beijing 100049 P. R. China.
Nanoscale Adv. 2023 Aug 8;5(18):4670-4674. doi: 10.1039/d3na00396e. eCollection 2023 Sep 12.
This work exploits the magneto-optical activity of gold nanorods for the detection of sub-micromolar concentrations of glutathione using magnetic circular dichroism spectroscopy. Modulations of the magnetoplasmonic response of nanorods serve as the basis of the sensing methodology, whereby the presence of glutathione induces the end-to-end assembly of nanorods. In particular, the nanorod self-assembly enables a localized electric field in the nanocavities with adsorbed thiol molecules, whose field strength is amplified by the external magnetic field as confirmed by finite-element modeling, enabling their high-sensitivity detection. Our simple magnetoplasmonic sensor for glutathione requires no specific chemical tags and exhibits an impressive limit of detection of 97 nM.
这项工作利用金纳米棒的磁光活性，通过磁圆二色光谱法检测亚微摩尔浓度的谷胱甘肽。纳米棒磁等离子体响应的调制作为传感方法的基础，谷胱甘肽的存在会诱导纳米棒的端对端组装。特别是，纳米棒自组装在吸附有硫醇分子的纳米腔中产生局部电场，有限元建模证实其场强会被外部磁场放大，从而实现高灵敏度检测。我们用于检测谷胱甘肽的简单磁等离子体传感器无需特定化学标签，检测限低至97 nM，令人印象深刻。
