Tsurugizawa Tomokazu, Taki Ai, Zalesky Andrew, Kasahara Kazumi
Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba-City, Ibaraki 305-8568, Japan.
Faculty of Engineering, Information and Systems, University of Tsukuba, Tsukuba 305-8573, Japan.
iScience. 2023 Aug 19;26(9):107592. doi: 10.1016/j.isci.2023.107592. eCollection 2023 Sep 15.
Hand preference is one of the behavioral expressions of lateralization in the brain. Previous fMRI studies showed the activation in several regions including the motor cortex and the cerebellum during single-hand movement. However, functional connectivity related to hand preference has not been investigated. Here, we used the generalized psychophysiological interaction (gPPI) approach to investigate the alteration of functional connectivity during single-hand movement from the resting state in right-hand subjects. The functional connectivity in interhemispheric motor-related regions including the supplementary motor area, the precentral gyrus, and the cerebellum was significantly increased during non-dominant hand movement, while functional connectivity was not increased during dominant hand movement. The general linear model (GLM) showed activation in contralateral supplementary motor area, contralateral precentral gyrus, and ipsilateral cerebellum during right- or left-hand movement. These results indicate that a combination of GLM and gPPI analysis can detect the lateralization of hand preference more clearly.
利手是大脑偏侧化的行为表现之一。先前的功能磁共振成像（fMRI）研究表明，单手运动期间包括运动皮层和小脑在内的几个区域会被激活。然而，与利手相关的功能连接尚未得到研究。在此，我们使用广义心理生理交互作用（gPPI）方法来研究右利手受试者从静息状态进行单手运动时功能连接的变化。在非优势手运动期间，包括辅助运动区、中央前回和小脑在内的半球间运动相关区域的功能连接显著增加，而在优势手运动期间功能连接并未增加。一般线性模型（GLM）显示，在右手或左手运动期间，对侧辅助运动区、对侧中央前回和同侧小脑会被激活。这些结果表明，GLM和gPPI分析相结合可以更清晰地检测到利手的偏侧化。
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