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丙泊酚与七氟醚麻醉对胶质瘤手术期间分子亚型及免疫检查点的影响

Impact of propofol versus sevoflurane anesthesia on molecular subtypes and immune checkpoints of glioma during surgery.

作者信息

Cen Shenghua, Yang Guocai, Bao Hongyan, Yu Ze, Liang Lei

机构信息

Department of Anesthesiology, Zhoushan Hospital Wenzhou Medical University Zhoushan Zhejiang China.

Department of Thoracic Surgery, Zhoushan Hospital Wenzhou Medical University Zhoushan Zhejiang China.

出版信息

Health Sci Rep. 2023 Sep 11;6(9):e1366. doi: 10.1002/hsr2.1366. eCollection 2023 Sep.

DOI:10.1002/hsr2.1366
PMID:37706017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10495545/
Abstract

BACKGROUND

Sevoflurane and propofol are two popular anesthetics used during glioblastoma (GBM) surgery. This investigation compared the molecular subtypes and immune checkpoints of cancer cells following GBM surgery under sevoflurane and propofol anesthesia.

METHOD

The expression profile data and clinical information of glioma samples of different grades were downloaded from The Cancer Genome Atlas database. Weighted gene coexpression network analysis was used to identify hub modules and key genes related to glioma grades (G2 and G3). The GEO database (GSE179004) was used to retrieve glioma surgical specimens with different anesthetic gene expression profiles. The differential expression of immune checkpoint genes under various anesthetic settings was examined using the R-ggplot2.

RESULTS

Compared to sevoflurane, propofol significantly downregulated SERPINI1 and CAMK2A expression. These are also important factors in glioma grading. Simultaneously, SERPINI1 and CAMK2A were also significantly related to the prognosis of GBM and lower-grade glioma patients and acted as potential tumor suppressors. In addition, propofol increases the expression of the immune checkpoint molecule, PD-L1.

CONCLUSIONS

Our study revealed that sevoflurane can more effectively prevent the development of glioma after surgery than propofol, and SERPINI1 can be used as a new independent prognostic factor for glioma.

摘要

背景

七氟醚和丙泊酚是胶质母细胞瘤（GBM）手术中常用的两种麻醉剂。本研究比较了七氟醚和丙泊酚麻醉下GBM手术后癌细胞的分子亚型和免疫检查点。

方法

从癌症基因组图谱数据库下载不同级别胶质瘤样本的表达谱数据和临床信息。采用加权基因共表达网络分析来识别与胶质瘤级别（G2和G3）相关的枢纽模块和关键基因。利用基因表达综合数据库（GSE179004）检索具有不同麻醉基因表达谱的胶质瘤手术标本。使用R-ggplot2检查各种麻醉设置下免疫检查点基因的差异表达。

结果

与七氟醚相比，丙泊酚显著下调了丝氨酸蛋白酶抑制剂I1（SERPINI1）和钙/钙调蛋白依赖蛋白激酶2A（CAMK2A）的表达。这些也是胶质瘤分级的重要因素。同时，SERPINI1和CAMK2A也与GBM和低级别胶质瘤患者的预后显著相关，并作为潜在的肿瘤抑制因子。此外，丙泊酚增加了免疫检查点分子程序性死亡受体配体1（PD-L1）的表达。

结论

我们的研究表明，七氟醚比丙泊酚能更有效地预防术后胶质瘤的发展，并且SERPINI1可作为胶质瘤新的独立预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/da325f485125/HSR2-6-e1366-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/2ad7fab5a2d4/HSR2-6-e1366-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/2c90d35e2aac/HSR2-6-e1366-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/0ce597e7edfc/HSR2-6-e1366-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/7eb96cf8bd94/HSR2-6-e1366-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/9edf76041e08/HSR2-6-e1366-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/da325f485125/HSR2-6-e1366-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/2ad7fab5a2d4/HSR2-6-e1366-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/2c90d35e2aac/HSR2-6-e1366-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/0ce597e7edfc/HSR2-6-e1366-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/7eb96cf8bd94/HSR2-6-e1366-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/9edf76041e08/HSR2-6-e1366-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b6/10495545/da325f485125/HSR2-6-e1366-g005.jpg

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