Haraguchi Takafumi, Matsuoka Shin, Yagihashi Kunihiro, Matsushita Shoichiro, Yamashiro Tsuneo, Kobayashi Yasuyuki, Mimura Hidefumi
From the Department of Radiology, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki, Japan.
J Comput Assist Tomogr. 2023;47(5):746-752. doi: 10.1097/RCT.0000000000001482. Epub 2023 May 26.
This study aimed to investigate the difference between the extent of centrilobular emphysema (CLE) and paraseptal emphysema (PSE) on follow-up chest CT scans and their relationship to the cross-sectional area (CSA) of small pulmonary vessels.
Sixty-two patients (36 CLE and 26 PSE) who underwent 2 chest CT scans were enrolled in this study. The percentage of low attenuation volume (%LAV) and total CSA of the small pulmonary vessels <5 mm 2 (%CSA < 5) were measured at the 2 time points. Analysis of the initial %CSA < 5 and the change in the %LAV and %CSA < 5 on follow-up imaging was performed.
The initial %CSA < 5 was not significantly different between the CLE and the PSE groups (CLE, 0.66 vs. PSE, 0.71; P = 0.78). There was no significant difference in the longitudinal change in the %LAV between the 2 groups (CLE, -0.048% vs. PSE, 0.005%; P = 0.26). The longitudinal change in the %CSA < 5 in patients with PSE significantly decreased compared with those with CLE (CLE, 0.025% vs. PSE, -0.018%; P = 0.02).
The longitudinal change in the %CSA < 5 was significantly different for patients with CLE and PSE, demonstrating an important pathophysiological difference between the subtypes.
本研究旨在调查随访胸部CT扫描中小叶中心型肺气肿（CLE）和间隔旁型肺气肿（PSE）的程度差异及其与小肺血管横截面积（CSA）的关系。
本研究纳入了62例接受了两次胸部CT扫描的患者（36例CLE和26例PSE）。在两个时间点测量低衰减体积百分比（%LAV）和直径<5 mm的小肺血管总横截面积百分比（%CSA < 5）。对初始%CSA < 5以及随访影像中%LAV和%CSA < 5的变化进行分析。
CLE组和PSE组的初始%CSA < 5无显著差异（CLE为0.66，PSE为0.71；P = 0.78）。两组之间%LAV的纵向变化无显著差异（CLE为-0.048%，PSE为0.005%；P = 0.26）。与CLE患者相比，PSE患者的%CSA < 5纵向变化显著降低（CLE为0.025%，PSE为-0.018%；P = 0.02）。
CLE和PSE患者的%CSA < 5纵向变化存在显著差异，表明这两种亚型之间存在重要的病理生理差异。
