Family Health, Mental Heath Department, High Institute of Public Health, Alexandria, Egypt.
Faculty of Medicine, General Surgery Department, Alexandria University, Alexandria, Egypt.
BMC Psychiatry. 2023 Sep 14;23(1):670. doi: 10.1186/s12888-023-05160-6.
No definite biomarker linking depression and obesity has been found yet. Our study aimed to investigate neuregulin-1 (NRG-1) as a potential blood biomarker for this association.
A case-control study was conducted on 108 obese subjects assigned for laparoscopic sleeve gastrectomy and 100 non-obese controls. Depression was assessed pre- and post-operatively. Serum NRG-1 was measured.
Pre-operatively depression was significantly higher among obese compared to non-obese patients. After the operation, 1.9% of the severely depressed subjects reported no depression, while 5.6% became moderately depressed; about 6% of the moderately depressed and 16% of the mildly depressed became not depressed. Serum NRG-1 level was significantly lower among obese and severely depressed compared to the controls. It was negatively correlated to the level of depression pre- and post-operative (r = -0.764 and -0.467 respectively). The sensitivity of serum NRG1 as a predictor for depression pre- and post-operative was 92.45% and 52.94% respectively. Specificity was 69.09% and 79.73% respectively at cut-off values of ≤ 3.5 and ≤ 2.5 ng/ml.
NRG-1 is a possible biomarker for the diagnosis of depression pre-bariatric surgery and the prediction of its prognosis post-operatively.
目前尚未发现与抑郁和肥胖相关的明确生物标志物。本研究旨在探讨神经调节蛋白-1（NRG-1）是否可作为两者相关的潜在血液生物标志物。
对 108 名拟行腹腔镜袖状胃切除术的肥胖患者和 100 名非肥胖对照者进行病例对照研究。术前和术后评估抑郁情况。检测血清 NRG-1。
与非肥胖患者相比，肥胖患者术前抑郁明显更高。术后，5.6%的重度抑郁患者报告无抑郁，1.9%的患者转为中度抑郁；约 6%的中度抑郁和 16%的轻度抑郁患者转为无抑郁。与对照组相比，肥胖和重度抑郁患者的血清 NRG-1 水平明显较低。它与术前和术后的抑郁水平呈负相关（分别为 r=-0.764 和-0.467）。术前和术后血清 NRG1 作为抑郁预测因子的灵敏度分别为 92.45%和 52.94%。截断值分别为≤3.5 和≤2.5ng/ml 时，特异性分别为 69.09%和 79.73%。
NRG-1 可能是肥胖患者术前诊断抑郁和预测术后预后的生物标志物。
