神经调节蛋白-1（NRG-1）是否是将抑郁与肥胖联系起来的潜在血液生物标志物？一项病例对照研究。

Is neuregulin-1 (NRG-1) a potential blood biomarker linking depression to obesity? A case-control study.

机构信息

Family Health, Mental Heath Department, High Institute of Public Health, Alexandria, Egypt.

Faculty of Medicine, General Surgery Department, Alexandria University, Alexandria, Egypt.

出版信息

BMC Psychiatry. 2023 Sep 14;23(1):670. doi: 10.1186/s12888-023-05160-6.

DOI:10.1186/s12888-023-05160-6

PMID:37710187

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10503040/

Abstract

BACKGROUND AND AIM

No definite biomarker linking depression and obesity has been found yet. Our study aimed to investigate neuregulin-1 (NRG-1) as a potential blood biomarker for this association.

METHODS

A case-control study was conducted on 108 obese subjects assigned for laparoscopic sleeve gastrectomy and 100 non-obese controls. Depression was assessed pre- and post-operatively. Serum NRG-1 was measured.

RESULTS

Pre-operatively depression was significantly higher among obese compared to non-obese patients. After the operation, 1.9% of the severely depressed subjects reported no depression, while 5.6% became moderately depressed; about 6% of the moderately depressed and 16% of the mildly depressed became not depressed. Serum NRG-1 level was significantly lower among obese and severely depressed compared to the controls. It was negatively correlated to the level of depression pre- and post-operative (r = -0.764 and -0.467 respectively). The sensitivity of serum NRG1 as a predictor for depression pre- and post-operative was 92.45% and 52.94% respectively. Specificity was 69.09% and 79.73% respectively at cut-off values of ≤ 3.5 and ≤ 2.5 ng/ml.

CONCLUSION

NRG-1 is a possible biomarker for the diagnosis of depression pre-bariatric surgery and the prediction of its prognosis post-operatively.

摘要

背景与目的

目前尚未发现与抑郁和肥胖相关的明确生物标志物。本研究旨在探讨神经调节蛋白-1（NRG-1）是否可作为两者相关的潜在血液生物标志物。

方法

对 108 名拟行腹腔镜袖状胃切除术的肥胖患者和 100 名非肥胖对照者进行病例对照研究。术前和术后评估抑郁情况。检测血清 NRG-1。

结果

与非肥胖患者相比，肥胖患者术前抑郁明显更高。术后，5.6%的重度抑郁患者报告无抑郁，1.9%的患者转为中度抑郁；约 6%的中度抑郁和 16%的轻度抑郁患者转为无抑郁。与对照组相比，肥胖和重度抑郁患者的血清 NRG-1 水平明显较低。它与术前和术后的抑郁水平呈负相关（分别为 r=-0.764 和-0.467）。术前和术后血清 NRG1 作为抑郁预测因子的灵敏度分别为 92.45%和 52.94%。截断值分别为≤3.5 和≤2.5ng/ml 时，特异性分别为 69.09%和 79.73%。