Katsogridaki Georgia, Tzovaras George, Sioka Eleni, Perivoliotis Konstantinos, Zachari Eleni, Magouliotis Dimitrios, Tasiopoulou Vassiliki, Zacharoulis Dimitrios
Department of Surgery, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Department of Surgery, Iaso Thessalias, Larissa, Greece.
Clin Obes. 2019 Apr;9(2):e12296. doi: 10.1111/cob.12296. Epub 2019 Feb 27.
The aim of this study was to evaluate the prevalence of hyperuricemia and acute gout after laparoscopic sleeve gastrectomy (LSG). Risk factors for developing gout were also examined. Eighty-five patients underwent LSG were enrolled in this prospective study. Serum uric acid levels, gout attacks and total water levels % derived by bioimpedance were examined pre-operatively and 1 month post-operatively. Hyperuricemia was identified in 30.6% pre-operatively and in 18.82% of patients post-operatively. From the patients' group with pre-operative hyperuricemia, 53.9% were normalized, 46.2% had increased uric acid post-operatively while gout was observed in 11.5%. From the patients group without pre-operative hyperuricemia, hyperuricemia and gout were observed in 6.8% and 5.1% post-operatively, respectively. The relative risk for developing hyperuricemia was 6.2 (95% confidence interval [CI] 2.2-17.8) and for developing gout was 2.3 (95% CI 2.2-17.8). Statistical significant differences for gout among the groups with and without gout were indicated concerning pre-operative use of medications (P < 0.001), age (P = 0.025), post-operative uric acid levels (P < 0.001) and post-operative total water levels % (P = 0.048). The prevalence of hyperuricemia was 18.8% and gout attack of 7.1% 1 month after LSG. From the cohort of patients with pre-operative hyperuricemia, a significant proportion normalized uric acid, while 11.5% developed gout. Patients without hyperuricemia pre-operatively developed hyperuricemia and gout in 6.8% and 5.1% post-operatively, respectively. The patients who had gout were younger and had 37% water levels post-operatively.
本研究旨在评估腹腔镜袖状胃切除术（LSG）后高尿酸血症和急性痛风的患病率。同时也对痛风发生的危险因素进行了研究。85例行LSG的患者纳入了这项前瞻性研究。术前及术后1个月检测血清尿酸水平、痛风发作情况以及通过生物电阻抗得出的总体水含量百分比。术前高尿酸血症的发生率为30.6%，术后为18.82%。术前有高尿酸血症的患者组中，53.9%尿酸水平恢复正常，46.2%术后尿酸升高，11.5%出现痛风。术前无高尿酸血症的患者组中，术后高尿酸血症和痛风的发生率分别为6.8%和5.1%。发生高尿酸血症的相对风险为6.2（95%置信区间[CI] 2.2 - 17.8），发生痛风的相对风险为2.3（95% CI 2.2 - 17.8）。有痛风和无痛风组之间在术前用药情况（P < 0.001）、年龄（P = 0.025）、术后尿酸水平（P < 0.001）以及术后总体水含量百分比（P = 0.048）方面，痛风存在统计学显著差异。LSG术后1个月高尿酸血症患病率为18.8%，痛风发作率为7.1%。术前有高尿酸血症的患者队列中，相当一部分尿酸水平恢复正常，而11.5%发生痛风。术前无高尿酸血症的患者术后分别有6.8%发生高尿酸血症和5.1%发生痛风。痛风患者更年轻，术后总体水含量为37%。
