Zeng Shuai, Liu Yijun, Fan Ping, Yang Luming, Liu Xinghui
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; Laboratory of Genetic Disease and Perinatal Medicine, Laboratory of the Key Perinatal Disease and Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Laboratory of Genetic Disease and Perinatal Medicine, Laboratory of the Key Perinatal Disease and Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Placenta. 2023 Oct;142:128-134. doi: 10.1016/j.placenta.2023.09.005. Epub 2023 Sep 10.
Preeclampsia (PE) is a severe pregnancy complication. The exact pathogenesis of PE remains unclear, but it is related to immune, inflammatory, circulatory, and oxidative stress factors. Leptin is a protein involved in these processes and is essential for maintaining a normal pregnancy and healthy fetal growth. Abnormal increases in leptin levels have been observed in the peripheral blood and placenta of patients with PE. Disturbances in leptin can affect the proliferation and hypertrophy of vascular smooth muscle cells, which are important for placentation. Leptin also regulates arterial tension and trophoblast function in pregnant women. In addition, consistently high levels of leptin are linked to hyperactive inflammation and oxidative stress reactions in both patients with PE and animal models. This review focuses on the role of leptin in the pathophysiology of PE and elucidates its potential mechanisms.
子痫前期（PE）是一种严重的妊娠并发症。PE的确切发病机制尚不清楚，但它与免疫、炎症、循环和氧化应激因素有关。瘦素是一种参与这些过程的蛋白质，对维持正常妊娠和胎儿健康生长至关重要。在PE患者的外周血和胎盘中观察到瘦素水平异常升高。瘦素紊乱会影响血管平滑肌细胞的增殖和肥大，而这对胎盘形成很重要。瘦素还调节孕妇的动脉张力和滋养层功能。此外，在PE患者和动物模型中，持续高水平的瘦素都与炎症和氧化应激反应过度活跃有关。本综述重点关注瘦素在PE病理生理学中的作用，并阐明其潜在机制。
