Academician Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China; Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nano-safety, Institute of High Energy Physics, Beijing 100049, China; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing 100190, China; Center of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
Acta Biomater. 2023 Nov;171:37-67. doi: 10.1016/j.actbio.2023.09.011. Epub 2023 Sep 14.
Coronary heart disease (CHD) is one of the major causes of death and disability worldwide, especially in low- and middle-income countries and among older populations. Conventional diagnostic and therapeutic approaches have limitations such as low sensitivity, high cost and side effects. Nanotechnology offers promising alternative strategies for the diagnosis and treatment of CHD by exploiting the unique properties of nanomaterials. In this review, we use bibliometric analysis to identify research hotspots in the application of nanotechnology in CHD and provide a comprehensive overview of the current state of the art. Nanomaterials with enhanced imaging and biosensing capabilities can improve the early detection of CHD through advanced contrast agents and high-resolution imaging techniques. Moreover, nanomaterials can facilitate targeted drug delivery, tissue engineering and modulation of inflammation and oxidative stress, thus addressing multiple aspects of CHD pathophysiology. We discuss the application of nanotechnology in CHD diagnosis (imaging and sensors) and treatment (regulation of macrophages, cardiac repair, anti-oxidative stress), and provide insights into future research directions and clinical translation. This review serves as a valuable resource for researchers and clinicians seeking to harness the potential of nanotechnology in the management of CHD. STATEMENT OF SIGNIFICANCE: Coronary heart disease (CHD) is the one of leading cause of death and disability worldwide. Nanotechnology offers new strategies for diagnosing and treating CHD by exploiting the unique properties of nanomaterials. This review uses bibliometric analysis to uncover research trends in the use of nanotechnology for CHD. We discuss the potential of nanomaterials for early CHD detection through advanced imaging and biosensing, targeted drug delivery, tissue engineering, and modulation of inflammation and oxidative stress. We also offer insights into future research directions and potential clinical applications. This work aims to guide researchers and clinicians in leveraging nanotechnology to improve CHD patient outcomes and quality of life.
冠心病（CHD）是全球主要的死亡和残疾原因之一，尤其在中低收入国家和老年人群中更为常见。传统的诊断和治疗方法存在局限性，如灵敏度低、成本高和副作用等。纳米技术通过利用纳米材料的独特性质，为 CHD 的诊断和治疗提供了有前途的替代策略。在本综述中，我们使用文献计量分析来确定纳米技术在 CHD 应用中的研究热点，并全面概述当前的技术现状。具有增强成像和生物传感能力的纳米材料可以通过先进的造影剂和高分辨率成像技术提高 CHD 的早期检测。此外，纳米材料可以促进靶向药物输送、组织工程和炎症及氧化应激的调节，从而解决 CHD 病理生理学的多个方面。我们讨论了纳米技术在 CHD 诊断（成像和传感器）和治疗（调节巨噬细胞、心脏修复、抗氧化应激）中的应用，并提供了对未来研究方向和临床转化的见解。本综述为寻求利用纳米技术管理 CHD 的研究人员和临床医生提供了有价值的资源。
意义声明：冠心病（CHD）是全球导致死亡和残疾的主要原因之一。纳米技术通过利用纳米材料的独特性质，为 CHD 的诊断和治疗提供了新策略。本综述使用文献计量分析揭示了纳米技术在 CHD 中的应用研究趋势。我们讨论了纳米材料在通过先进的成像和生物传感、靶向药物输送、组织工程和调节炎症及氧化应激来早期检测 CHD 方面的潜力。我们还提供了对未来研究方向和潜在临床应用的见解。这项工作旨在指导研究人员和临床医生利用纳米技术改善 CHD 患者的治疗效果和生活质量。
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