Ni Ping, Dai Liming, Li Hai, Sun Jun, Zhu Yicheng, Lv Xiaolei
Department of Cardiology, The Third People's Hospital of Kunshan, Kunshan, 215300, China.
Department of Cardiology, The First People's Hospital of Kunshan, No. 566 East Qianjin Road, Kunshan, 215300, Jiangsu, China.
J Cardiothorac Surg. 2025 May 30;20(1):249. doi: 10.1186/s13019-025-03490-y.
Coronary heart disease (CHD) is a chronic inflammatory disease carrying high morbidity and mortality. Interleukin (IL)-29 may be used as a biomarker for autoimmune diseases. This paper investigates the diagnostic value of serum IL-29 in CHD patients.
A total of 90 CHD patients (39 mild and 51 severe patients) and 90 controls were included. Serum IL-29 levels were detected by ELISA, and the diagnostic value of IL-29 in CHD was analyzed by ROC curve. According to the median value of serum IL-29 level, CHD patients were categorized into IL-29 low-level group and high-level group. The correlation between IL-29 and pathological indexes of CHD patients was analyzed by chi-square test. SYNTAX score was used to classify CHD patients into mild CHD and moderate/severe CHD. Pearson coefficient analyzed the correlation between IL-29 and CHD severity. Multivariate logistic regression analyzed the risk factors for CHD exacerbation.
IL-29 serum levels were elevated in CHD patients. The AUC for CHD diagnosis by serum IL-29 was 0.789 (65.6% sensitivity and 76.7% specificity). IL-29 was correlated with BMI, PHASE score, and CRP. IL-29 serum level was positively correlated with CHD severity. The AUC for differentiating mild and moderate/severe CHD patients by IL-29 level was 0.739 (70.6% sensitivity and 66.7% specificity). IL-29 was an independent risk factor for CHD exacerbation, and each one-unit increase in IL-29 increased the risk of exacerbation in CHD patients by 1.065-fold.
IL-29 is highly expressed in CHD patients and has auxiliary diagnostic value for CHD.
冠心病（CHD）是一种发病率和死亡率都很高的慢性炎症性疾病。白细胞介素（IL）-29可用作自身免疫性疾病的生物标志物。本文研究血清IL-29在冠心病患者中的诊断价值。
共纳入90例冠心病患者（39例轻度患者和51例重度患者）和90例对照。采用酶联免疫吸附测定法检测血清IL-29水平，并通过受试者工作特征（ROC）曲线分析IL-29对冠心病的诊断价值。根据血清IL-29水平的中位数，将冠心病患者分为IL-29低水平组和高水平组。采用卡方检验分析IL-29与冠心病患者病理指标之间的相关性。采用SYNTAX评分将冠心病患者分为轻度冠心病和中度/重度冠心病。采用Pearson系数分析IL-29与冠心病严重程度之间的相关性。采用多因素logistic回归分析冠心病病情加重的危险因素。
冠心病患者血清IL-29水平升高。血清IL-29诊断冠心病的曲线下面积（AUC）为0.789（灵敏度65.6%，特异度76.7%）。IL-29与体重指数（BMI）、阶段评分和C反应蛋白（CRP）相关。血清IL-29水平与冠心病严重程度呈正相关。IL-29水平鉴别轻度和中度/重度冠心病患者的AUC为0.739（灵敏度70.6%，特异度66.7%）。IL-29是冠心病病情加重的独立危险因素，IL-29每升高一个单位，冠心病患者病情加重的风险增加1.065倍。
IL-29在冠心病患者中高表达，对冠心病有辅助诊断价值。
