Western University of Health Sciences, College of Dental Medicine, 309 E. 2nd Street, Pomona, CA 91766, USA.
Western University of Health Sciences, College of Dental Medicine, 309 E. 2nd Street, Pomona, CA 91766, USA.
Dent Clin North Am. 2023 Oct;67(4):581-584. doi: 10.1016/j.cden.2023.05.005. Epub 2023 Jul 3.
Chronic exposure to endogenous and exogenous glucocorticoids will cause CS. Endogenous CS is uncommon, with an annual incidence of 0.2-5 individuals per million. Endogenous causes could be 1. adrenocorticotropic hormone (ACTH) dependent or 2. ACTH independent. The use of exogenous glucocorticoids to manage chronic autoimmune or inflammatory diseases is the most common cause of CS and results in iatrogenic CS. Cushing disease is caused by excess ACTH production by a pituitary tumor. CS's clinical manifestations in the head and neck region include a moon-shaped face, acne flares, and hirsutism.
慢性暴露于内源性和外源性糖皮质激素会导致库欣综合征。内源性库欣综合征并不常见，年发病率为每百万人中有 0.2-5 人。内源性原因可能是 1. 促肾上腺皮质激素（ACTH）依赖性或 2. ACTH 非依赖性。使用外源性糖皮质激素来治疗慢性自身免疫或炎症性疾病是库欣综合征最常见的原因，导致医源性库欣综合征。库欣病是由垂体瘤分泌过多的 ACTH 引起的。库欣综合征在头颈部的临床表现包括满月脸、痤疮发作和多毛症。
