Nasrallah H A, Varney N, Coffman J A, Bayless J, Chapman S
J Clin Psychiatry. 1986 Nov;47(11):555-6.
The opiate antagonist naloxone has been reported to improve memory in animals and to produce partial improvement in Alzheimer's dementia. The usefulness of naloxone for reversing ECT-induced cognitive impairment was tested by comparing the effects of naloxone and placebo on several tests of cognitive performance in 10 patients who underwent bilateral ECT. No significant differences were found between naloxone and placebo. The results suggest that at the doses used, naloxone is not effective in reversing ECT-induced memory deficits.
据报道，阿片类拮抗剂纳洛酮可改善动物的记忆力，并使阿尔茨海默病性痴呆症得到部分改善。通过比较纳洛酮和安慰剂对10例接受双侧电休克治疗（ECT）患者的多项认知功能测试的影响，来测试纳洛酮逆转ECT引起的认知障碍的有效性。纳洛酮和安慰剂之间未发现显著差异。结果表明，在所使用的剂量下，纳洛酮对逆转ECT引起的记忆缺陷无效。
