Inspection Center, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei050031, China.
Department of Blood Transfusion, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei050031, China.
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):80-84. doi: 10.14715/cmb/2023.69.7.13.
Cervical cancer is the second leading cause of cancer death among women worldwide. Identification of effective genes along with biological markers as targeting agents is very necessary for the diagnosis and treatment of this disease. Bioinformatics techniques along with genetic and molecular investigations have provided the possibility of studying different levels of information such as the genome, transcriptome, proteome, and metabolize with high depth and accuracy. The collection of these data provides comprehensive and valuable information about the investigated phenotypes, including complex diseases such as cancer. In this study, we examined three genes LRP11, FUBP1, and TET1 related to cervical cancer. The results of this study showed that the level of expression of these genes is high in lymph nodes and the thyroid and is less in the pancreas and liver. Also, the expression level of the FUBP1 gene is higher than that of LRP11, and the expression level of the LRP11 gene is higher than that of TET1. Regarding the structure and proteomics of the studied genes, it can be seen that due to the presence of more domains in the LRP11 and FUBP1 genes, these genes probably independently participate in various functions and have a wider range of activity than the TET1 gene. Also, the analysis of the stability of the examined genes showed that the stability of the FUBP1 gene is relatively higher than that of the TET1 gene, and this gene is also more stable than the LRP11 gene. Considering that these genes are effective key genes for the early detection of cervical cancer, it is hoped that they will be used as markers in the diagnosis and treatment of cervical cancer.
宫颈癌是全球女性癌症死亡的第二大主要原因。鉴定有效的基因和生物标志物作为靶向治疗剂对于该疾病的诊断和治疗非常必要。生物信息学技术以及遗传和分子研究为研究不同层次的信息提供了可能性，例如基因组、转录组、蛋白质组和代谢组，具有高深度和准确性。这些数据的收集提供了有关所研究表型的全面和有价值的信息，包括癌症等复杂疾病。在这项研究中，我们研究了与宫颈癌相关的三个基因 LRP11、FUBP1 和 TET1。研究结果表明，这些基因在淋巴结和甲状腺中的表达水平较高，在胰腺和肝脏中的表达水平较低。此外，FUBP1 基因的表达水平高于 LRP11，而 LRP11 基因的表达水平高于 TET1。关于研究基因的结构和蛋白质组学，可以看出由于 LRP11 和 FUBP1 基因中存在更多的结构域，这些基因可能独立参与各种功能，并且比 TET1 基因具有更广泛的活性范围。此外，对所研究基因稳定性的分析表明，FUBP1 基因的稳定性相对高于 TET1 基因，并且该基因也比 LRP11 基因更稳定。鉴于这些基因是早期检测宫颈癌的有效关键基因，希望它们能作为宫颈癌诊断和治疗的标志物。
