Institute of Psychiatry, Psychology and Neuroscience, King's College London, Department of Psychology, London, UK.
Institute of Psychiatry, Psychology and Neuroscience, King's College London, Department of Psychology, London, UK; South London and Maudsley NHS Foundation Trust (SLaM), PICuP (Psychological Interventions Clinic for outpatients with Psychosis), UK.
J Behav Ther Exp Psychiatry. 2024 Mar;82:101911. doi: 10.1016/j.jbtep.2023.101911. Epub 2023 Sep 12.
Depersonalisation/derealisation symptoms are prevalent in psychosis patients, are associated with increased impairment, and may maintain psychosis symptoms. We aimed to establish the feasibility and acceptability of a brief, six session therapy protocol adapted from a Cognitive-Behavioural model of Depersonalisation-Derealisation Disorder (DDD) in participants with psychotic symptoms.
A single-blind, randomised controlled trial was conducted with a treatment-as-usual control condition. Feasibility and acceptability estimates included rates of referral, acceptance, eligibility, consent, satisfaction and improved skills/knowledge to manage depersonalisation.
Twenty-one individuals were recruited to the trial. Results suggest that the intervention was feasible and acceptable to participants and there is some signal of effect on clinical outcomes.
There were some challenges in recruitment. Recruitment feasibility estimates from the research register used may not be informative for future trials recruiting directly from teams.
Overall, the results suggest that further investigations would be of interest and recommendations for this are made.
人格解体/现实解体症状在精神病患者中较为普遍，与功能损害增加有关，并且可能维持精神病症状。我们旨在确定从人格解体-现实解体障碍（DDD）的认知行为模型改编而来的简短六节治疗方案在有精神病症状的参与者中应用的可行性和可接受性。
进行了一项单盲、随机对照试验，设常规治疗对照组。可行性和可接受性评估包括转诊、接受、合格、同意、满意度以及改善管理人格解体的技能/知识的情况。
共有 21 名个体参与了试验。结果表明，该干预措施对参与者是可行和可接受的，并且对临床结局有一定的效果信号。
招募过程中存在一些挑战。从用于研究注册的招募可行性估计中可能无法获得有关未来从团队直接招募的试验的信息。
总体而言，结果表明进一步的研究将是有意义的，并提出了相关建议。
