Zhang Jie, Chen Ru, Chen Shuainan, Yu Die, Elkamchouchi Dalia H, Alqahtani Mohammed S, Assilzadeh Hamid, Huang Zhongguan, Huang Yideng
Department of Otolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang,325000, China.
Department of Otolaryngology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Environ Res. 2023 Dec 15;239(Pt 1):117115. doi: 10.1016/j.envres.2023.117115. Epub 2023 Sep 16.
Taking hearing loss as a prevalent sensory disorder, the restricted permeability of blood flow and the blood-labyrinth barrier in the inner ear pose significant challenges to transporting drugs to the inner ear tissues. The current options for hear loss consist of cochlear surgery, medication, and hearing devices. There are some restrictions to the conventional drug delivery methods to treat inner ear illnesses, however, different smart nanoparticles, including inorganic-based nanoparticles, have been presented to regulate drug administration, enhance the targeting of particular cells, and decrease systemic adverse effects. Zinc oxide nanoparticles possess distinct characteristics that facilitate accurate drug delivery, improved targeting of specific cells, and minimized systemic adverse effects. Zinc oxide nanoparticles was studied for targeted delivery and controlled release of therapeutic drugs within specific cells. XGBoost model is used on the Wideband Absorbance Immittance (WAI) measuring test after cochlear surgery. There were 90 middle ear effusion samples (ages = 1-10 years, mean = 34.9 months) had chronic middle ear effusion for four months and verified effusion for seven weeks. In this research, 400 sets underwent wideband absorbance imaging (WAI) to assess inner ear performance after surgery. Among them, 60 patients had effusion Otitis Media with Effusion (OME), while 30 ones had normal ears (control). OME ears showed significantly lower absorbance at 250, 500, and 1000 Hz than controls (p < 0.001). Absorbance thresholds >0.252 (1000 Hz) and >0.330 (2000 Hz) predicted a favorable prognosis (p < 0.05, odds ratio: 6). It means that cochlear surgery and WAI showed high function in diagnosis and treatment of inner ear infections. Regarding the R 0.899 and RMSE 1.223, XGBoost shows excellent specificity and sensitivity for categorizing ears as having effusions absent or present or partial or complete flows present, with areas under the curve (1-0.944).
听力损失作为一种常见的感觉障碍，内耳中血流和血迷路屏障的通透性受限，给将药物输送到内耳组织带来了重大挑战。目前治疗听力损失的方法包括耳蜗手术、药物治疗和听力设备。然而，传统的药物递送方法在治疗内耳疾病方面存在一些限制，不同的智能纳米颗粒，包括无机基纳米颗粒，已被用于调节药物给药、增强对特定细胞的靶向作用并减少全身不良反应。氧化锌纳米颗粒具有独特的特性，有助于精确给药、改善对特定细胞的靶向作用并将全身不良反应降至最低。研究了氧化锌纳米颗粒在特定细胞内的靶向递送和治疗药物的控释。XGBoost模型用于耳蜗手术后的宽带吸收导抗（WAI）测量测试。有90例中耳积液样本（年龄 = 1 - 10岁，平均 = 34.9个月）患有慢性中耳积液4个月且积液已证实7周。在本研究中，400例接受了宽带吸收成像（WAI）以评估术后内耳功能。其中，60例患者患有积液性中耳炎（OME），而30例耳朵正常（对照组）。OME耳朵在250、500和1000 Hz处的吸光度明显低于对照组（p < 0.001）。吸光度阈值>0.252（在频率1000 Hz时）和>0.330（在频率2000 Hz时）预示着良好的预后（p < 0.05，优势比：6）。这意味着耳蜗手术和WAI在诊断和治疗内耳感染方面显示出高效能。关于R值为0.899和均方根误差为1.223，XGBoost在将耳朵分类为有无积液或有无部分或完全血流方面显示出出色的特异性和敏感性，曲线下面积为（1 - 0.944）。
