Aleman Espino Andy, Aleman Espino Erik, Aleman Oliva Claudia, Monteagudo Hamlet, Frontela Odalys
Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.
Internal Medicine, Larkin Community Hospital Palm Springs Campus, Hialeah, USA.
Cureus. 2023 Sep 14;15(9):e45261. doi: 10.7759/cureus.45261. eCollection 2023 Sep.
Acute kidney injury (AKI) involves a rapid decline in kidney function, classified into prerenal, intrarenal, and postrenal causes. Drug-induced AKI's complex pathophysiology includes altered hemodynamics, inflammation, crystal deposition, hemolysis, and rhabdomyolysis. This report details a 42-year-old female with hypertension and diabetes who, following a dog bite, exhibited reduced kidney function (GFR: 16 mL/min/1.73m; BUN/Cr: 23/3.23 mg/dL). A renal ultrasound revealed no stones or masses, and the recent use of tirzepatide was identified. Discontinuation of the drug, IV fluid maintenance, and close monitoring led to swift kidney function improvement. This case underscores the importance of recognizing drug-induced AKI, even in unrelated complaints, and highlights the need for vigilance and research into the adverse effects of medications such as glucagon-like peptide 1 (GLP-1) receptor agonists.
急性肾损伤（AKI）是指肾功能迅速下降，分为肾前性、肾性和肾后性病因。药物性AKI复杂的病理生理学包括血流动力学改变、炎症、晶体沉积、溶血和横纹肌溶解。本报告详细介绍了一名42岁患有高血压和糖尿病的女性，在被狗咬伤后，肾功能下降（肾小球滤过率：16毫升/分钟/1.73平方米；血尿素氮/肌酐：23/3.23毫克/分升）。肾脏超声检查未发现结石或肿块，并确定近期使用了替尔泊肽。停用该药物、静脉补液维持治疗并密切监测后，肾功能迅速改善。该病例强调了即使在无关主诉中识别药物性AKI的重要性，并突出了对胰高血糖素样肽1（GLP-1）受体激动剂等药物不良反应进行警惕和研究的必要性。
