肿瘤蛋白β抑制蛋白-1与恶二唑化合物的分子对接分析
Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds.
作者信息
Sharma Vipra, Rengasamy Gayathri, Sekaran Surya, Sankaran Kavitha, Veeraraghavan Vishnu Priya, Eswaramoorthy Rajalakshmanan
机构信息
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India.
Department of Biomaterials (Green lab), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India.
出版信息
Bioinformation. 2023 Jan 31;19(1):111-116. doi: 10.6026/97320630019111. eCollection 2023.
Beta arrestins are a family of adaptor proteins that help in the regulation of signaling and trafficking of various G protein coupled receptors (GPCRs). Six oxadiazole derivatives taken from literature are analyzed for anti-cancer properties. The toxicity profiles of all the drugs were similar to Tamoxifen used as control. Data shows that compounds 2, 4, and 6 exhibited comparably significant molecular interactions with the cancerous protein for further consideration.
β-抑制蛋白是一类衔接蛋白，有助于调节各种G蛋白偶联受体（GPCR）的信号传导和转运。对文献中选取的六种恶二唑衍生物的抗癌特性进行了分析。所有药物的毒性特征均与用作对照的他莫昔芬相似。数据表明，化合物2、4和6与癌蛋白表现出相当显著的分子相互作用，值得进一步研究。
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