恶唑化合物与来自……的血红素结合蛋白的分子对接分析。 （注：原文中“from”后面缺少具体来源信息）
Molecular docking analysis of oxazole compounds with the heme-binding protein from .
作者信息
Manikandan Pranaw, Veeraraghavan Vishnu Priya, Sekaran Surya, Rengasamy Gayathri, Eswaramoorthy Rajalakshmanan
机构信息
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India.
Department of Biomaterials (Green lab), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai-600077, India.
出版信息
Bioinformation. 2023 Jan 31;19(1):105-110. doi: 10.6026/97320630019105. eCollection 2023.
, a peripathogen, has several methods to impede or modify the protective mechanisms of the teeth. Targeting the inhibition of the heme protein will prevent the organism from multiplying and inhibit the virulence mechanism. The literature derived oxazole compounds (1-5) were docked against the protein's active site, and the results show that the selected oxazole derivatives exhibit better interaction compared to clinically proven drugs.
一种牙周病原体有多种方法来阻碍或改变牙齿的保护机制。针对血红素蛋白的抑制将阻止该生物体繁殖并抑制其毒力机制。将文献中得到的恶唑化合物（1 - 5）与该蛋白的活性位点进行对接，结果表明与临床验证的药物相比，所选的恶唑衍生物表现出更好的相互作用。
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