Department of Clinical Medicine, Tongji University School of Medicine, Shanghai, China.
Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Front Endocrinol (Lausanne). 2023 Aug 30;14:1205408. doi: 10.3389/fendo.2023.1205408. eCollection 2023.
The maternal-fetal interface is defined as the interface between maternal tissue and sections of the fetus in close contact. RNA methylation modifications are the most frequent kind of RNA alterations. It is effective throughout both normal and pathological implantation and placentation during pregnancy. By influencing early embryo development, embryo implantation, endometrium receptivity, immune microenvironment, as well as some implantation and placentation-related disorders like miscarriage and preeclampsia, it is essential for the establishment of the maternal-fetal interface. Our review focuses on the role of dynamic RNA methylation at the maternal-fetal interface, which has received little attention thus far. It has given the mechanistic underpinnings for both normal and abnormal implantation and placentation and could eventually provide an entirely novel approach to treating related complications.
母子界面被定义为母体组织与胎儿紧密接触的部分之间的界面。RNA 甲基化修饰是最常见的 RNA 改变类型。它在妊娠期间的正常和病理植入和胎盘形成中都有效。通过影响早期胚胎发育、胚胎植入、子宫内膜容受性、免疫微环境以及一些与植入和胎盘相关的疾病，如流产和子痫前期，它对建立母子界面至关重要。我们的综述重点介绍了母子界面上动态 RNA 甲基化的作用，目前这方面的研究还很少。它为正常和异常的植入和胎盘形成提供了机制基础，并最终可能为治疗相关并发症提供一种全新的方法。
