Division of Medicine, Immanuel Kant Baltic Federal University, Kaliningrad, Kaliningrad, Russia.
Division of Medicine, Universitat Internacional de Catalunya, Barcelona, Spain.
Pediatr Dermatol. 2023 Nov-Dec;40(6):1060-1063. doi: 10.1111/pde.15419. Epub 2023 Sep 18.
Molluscum contagiosum (MC) is a contagious infection that, although benign, can become an aesthetic burden and lead to other opportunistic infections, secondary dermatitis, and self-isolation. Currently, several treatment options are available for MC, including the newly investigated nitric oxide-releasing berdazimer gel, leading this review to evaluate randomized controlled trials (RCT) comparing berdazimer gel with a vehicle for treating MC. The meta-analysis included three reports and four RCT involving 1854 patients, with 1106 (59.6%) randomized to receive berdazimer. Our findings suggest that berdazimer is effective in the management of MC lesions, but the increased clearance of lesions and reduction of scarring must be weighed against the potential for topical adverse effects, particularly when considering the use of this therapy in pediatric patients.
传染性软疣（MC）是一种传染性感染，虽然良性，但可能成为美学负担，并导致其他机会性感染、继发性皮炎和自我隔离。目前，有几种治疗 MC 的方法，包括新研究的一氧化氮释放贝达西莫尔凝胶，这促使本次综述评估了比较贝达西莫尔凝胶和载体治疗 MC 的随机对照试验（RCT）。荟萃分析包括三项报告和四项 RCT，涉及 1854 名患者，其中 1106 名（59.6%）被随机分配接受贝达西莫尔治疗。我们的研究结果表明，贝达西莫尔凝胶在 MC 病变的治疗中是有效的，但必须权衡病变清除率和疤痕减少率与局部不良反应的潜在风险，特别是在考虑将这种治疗方法用于儿科患者时。
