Costa P, Ohanna F, Martinazzo J, Grasset D
J Urol (Paris). 1986;92(3):147-52.
The vesico-sphincter dyssynergia is generally observed in paraplegic patients with supra sacral lesions (40% of our cases). The neurophysiologic basis of the vesico-sphincter dyssynergia are the field of controversies. The animal experimentations have shown that a section below the ponts, induce a neural reorganization, enough to produce a normal micturation, rising sacral short loop reflexes. The reality of such mechanism is discussed by different authors who consider a normal micturation as a brain stem reflex rather than a simple sacral reflex. These factors allow the authors to undergo a neurophysiologic, neuropharmacologic and urodynamic investigation, with the intention of shedding light on the pathophysiology of the vesico-sphincter dyssynergia in 20 cases of paraplegic patients. On the basis of our data the following conclusions were made: the importance of the polysynaptic reflexes evoked by cutaneous or vesical stimulation (below the neurologic lesions) on the different degrees of vesico-sphincter dyssynergia; the quality of voiding depends on the equilibrium between extension and flexor reflexes in paraplegic patients; the presence of a neural reorganization using short loop reflexes who are the expression of a complex system rather than a simple sacral reflex; the effect of chronic intrathecal morphinic drugs on the reflex equilibrium and the quality of voiding and the eventual relation between opiate receptors and vesical sphincter dyssynergia.
膀胱-括约肌协同失调通常见于骶上节段损伤的截瘫患者(占我们病例的40%)。膀胱-括约肌协同失调的神经生理学基础存在争议。动物实验表明,脑桥以下的横断会引起神经重组,足以产生正常排尿,增强骶部短回路反射。不同作者对这种机制的实际情况进行了讨论,他们认为正常排尿是一种脑干反射而非简单的骶反射。这些因素促使作者对20例截瘫患者进行神经生理学、神经药理学和尿动力学研究,以阐明膀胱-括约肌协同失调的病理生理学。根据我们的数据得出了以下结论:皮肤或膀胱刺激(在神经损伤以下)诱发的多突触反射对不同程度膀胱-括约肌协同失调的重要性;截瘫患者排尿的质量取决于伸展和屈肌反射之间的平衡;存在利用短回路反射的神经重组,这是一个复杂系统的表现而非简单的骶反射;慢性鞘内注射吗啡类药物对反射平衡和排尿质量的影响以及阿片受体与膀胱括约肌协同失调之间的最终关系。