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[通过经皮氧分压测量和远端动脉收缩压确定截肢平面]

[Determination of the amputation level by transcutaneous PO2 measurement and distal arterial systolic pressure].

作者信息

Depairon M, Krahenbuhl B, Vaucher J

出版信息

J Mal Vasc. 1986;11(3):229-34.

PMID:3772253
Abstract

Transcutaneous oxygen partial pressure measurement (TcPO2) using a polarographic probe heating the skin at 44 degrees C provides informations about the capacity of blood to supply skin with oxygen. As oxygen is necessary for tissue survival, TcPO2 could constitute an adequate parameter for the determination of an amputation level. Among 67 amputations performed between 1983 and, 1984, we included in this study 34 patients (35 amputations), in whom TcPO2 was preoperatively measured (24 males, 10 females, mean age 67 years, range 19-86 years). Twenty two were diabetics. Twenty patients suffered from severe ischemia (stage Fontaine 4); 13 patients suffered from chronic diabetic lesions or/and osteomyelitis and two patients suffered from frostbite. The follow-up period lasted until operative wound was healed or a more proximal amputation was undertaken (mean 2.5 months, range 15 days to 10 months). Five operative wounds did not heal, so that a more proximal amputation was undertaken. TcPO2 was below 20 mm Hg in 3 of these 5 patients. TcPO2 was above 20 mm Hg in 24 among 30 patients in whom operative wound healed. When TcPO2 is above 20 mm Hg, the probability of operative wound healing is 92%. When TcPO2 is below 20 mm Hg, the risk of a more proximal amputation is 33%. Distal systolic blood pressure has no predictive value. It is concluded than when TcPO2 is above 20 mm Hg, the probability of healing of operative wound is clinically acceptable. When TcPO2 is below 20 mm Hg, 1 of 3 patients will be reamputated at a more proximal level, but healing does occur in 66% of patients.

摘要

使用极谱探头在44摄氏度加热皮肤来进行经皮氧分压测量(TcPO2),可提供有关血液向皮肤供氧能力的信息。由于氧气是组织存活所必需的,TcPO2可能是确定截肢水平的一个合适参数。在1983年至1984年间进行的67例截肢手术中,我们将本研究纳入了34例患者(35例截肢手术),术前对他们进行了TcPO2测量(24例男性,10例女性,平均年龄67岁,范围为19至86岁)。22例为糖尿病患者。20例患有严重缺血(Fontaine 4期);13例患有慢性糖尿病病变或/和骨髓炎,2例患有冻伤。随访期持续至手术伤口愈合或进行更靠近近端的截肢手术(平均2.5个月,范围为15天至10个月)。5个手术伤口未愈合,因此进行了更靠近近端的截肢手术。这5例患者中有3例的TcPO2低于20 mmHg。在手术伤口愈合的30例患者中,24例的TcPO2高于20 mmHg。当TcPO2高于20 mmHg时,手术伤口愈合的概率为92%。当TcPO2低于20 mmHg时,进行更靠近近端截肢手术的风险为33%。远端收缩压没有预测价值。得出的结论是,当TcPO2高于20 mmHg时,手术伤口愈合的概率在临床上是可以接受的。当TcPO2低于20 mmHg时,3例患者中有1例将在更靠近近端的水平进行再次截肢,但66%的患者伤口确实会愈合。

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