儿童复发性和慢性胰腺炎的骨骼健康：一项多中心横断面分析。
Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis.
机构信息
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
出版信息
Pancreatology. 2023 Nov;23(7):755-760. doi: 10.1016/j.pan.2023.08.006. Epub 2023 Aug 31.
BACKGROUND/OBJECTIVES: Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied.
METHODS
This retrospective study was performed at three sites and included data from INSPPIRE-2.
RESULTS
Of the 87 children in the study: 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 ± 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score < -2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score < -2) (6.4%, 5/78) were higher than a healthy reference sample (2.5%, p < 0.0001 and p = 0.03, respectively).
CONCLUSION
Children with ARP or CP have lower height and BMD than healthy peers. Attention to deficits in growth and bone mineral accrual in children with pancreatic disease is warranted.
背景/目的：儿童急性复发性胰腺炎（ARP）和慢性胰腺炎（CP）的骨骼健康尚未得到充分研究。
方法
本回顾性研究在三个地点进行，纳入了 INSPPIRE-2 研究的数据。
结果
在研究的 87 名儿童中：46 名患有 ARP（53%），41 名患有 CP（47%）。最后一次 DXA 扫描时的平均年龄为 13.6±3.9 岁。身高低于年龄（Z 分数 < -2）的患病率（13%，10/78）和身高校正后的骨密度（BMD）低（Z 分数 < -2）（6.4%，5/78）均高于健康参考样本（分别为 2.5%，p<0.0001 和 p=0.03）。
结论
患有 ARP 或 CP 的儿童的身高和 BMD 低于健康同龄人。有必要关注患有胰腺疾病的儿童在生长和骨矿物质积累方面的缺陷。
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