Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Pancreatology. 2023 Nov;23(7):755-760. doi: 10.1016/j.pan.2023.08.006. Epub 2023 Aug 31.
BACKGROUND/OBJECTIVES: Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied.
This retrospective study was performed at three sites and included data from INSPPIRE-2.
Of the 87 children in the study: 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 ± 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score < -2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score < -2) (6.4%, 5/78) were higher than a healthy reference sample (2.5%, p < 0.0001 and p = 0.03, respectively).
Children with ARP or CP have lower height and BMD than healthy peers. Attention to deficits in growth and bone mineral accrual in children with pancreatic disease is warranted.
背景/目的：儿童急性复发性胰腺炎（ARP）和慢性胰腺炎（CP）的骨骼健康尚未得到充分研究。
本回顾性研究在三个地点进行，纳入了 INSPPIRE-2 研究的数据。
在研究的 87 名儿童中：46 名患有 ARP（53%），41 名患有 CP（47%）。最后一次 DXA 扫描时的平均年龄为 13.6±3.9 岁。身高低于年龄（Z 分数 < -2）的患病率（13%，10/78）和身高校正后的骨密度（BMD）低（Z 分数 < -2）（6.4%，5/78）均高于健康参考样本（分别为 2.5%，p<0.0001 和 p=0.03）。
患有 ARP 或 CP 的儿童的身高和 BMD 低于健康同龄人。有必要关注患有胰腺疾病的儿童在生长和骨矿物质积累方面的缺陷。
