Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Department of Endocrinology & Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China.
Endocr Metab Immune Disord Drug Targets. 2024;24(7):808-819. doi: 10.2174/1871530323666230918121353.
Selenium, a significant trace element needed by the human body, is closely related to thyroid. Therefore, this study aimed to explore the status of selenium and thyroid diseases, analyze emerging insights, and predict future trends.
Literature on selenium and thyroid included in the core database of Web of Science from January 1992 to October 2022 was retrieved. CiteSpace and VOSviewer software were used for visual analysis in terms of publication, author, country, institution, co-citation, and keywords.
A total of 1,142 works of literature were included after the screening, and the annual publication showed a fluctuating upward trend. The country and the institution with the highest publication volume were the United States and Charité Universitätsmedizin Berlin, respectively. In terms of authors, Schomburg L has formed a cooperative network and has published the largest number of papers and made great contributions in this field. The biggest cluster of keywords was trace elements, and the hot keywords in recent years were oxidative stress, Hashimoto's thyroiditis, cadmium, copper, etc. Conclusion: This paper analyzes the current status, insights, and trends of the studies on selenium and thyroid diseases by the method of bibliometrics and delivers ideas and methods for subsequent research in this field. The therapeutic effect of selenium on Hashimoto's thyroiditis is controversial and needs further research, and oxidative stress is also a research hotspot in this field. The crossstudy of multiple trace elements and diseases may be the development trend in the future.
硒是人体必需的重要微量元素，与甲状腺密切相关。因此，本研究旨在探讨硒与甲状腺疾病的现状，分析新出现的见解，并预测未来的趋势。
检索 1992 年 1 月至 2022 年 10 月 Web of Science 核心数据库中收录的有关硒与甲状腺的文献，使用 CiteSpace 和 VOSviewer 软件进行文献出版、作者、国家、机构、共被引和关键词的可视化分析。
筛选后共纳入 1142 篇文献，年发文量呈波动上升趋势。发文量最高的国家和机构分别是美国和柏林夏里特医科大学。在作者方面，Schomburg L 已形成合作网络，在该领域发表的论文数量最多，贡献最大。最大的关键词聚类是微量元素，近年来的热门关键词是氧化应激、桥本甲状腺炎、镉、铜等。
本研究采用文献计量学方法分析了硒与甲状腺疾病研究的现状、见解和趋势，为该领域的后续研究提供了思路和方法。硒对桥本甲状腺炎的治疗效果存在争议，需要进一步研究，氧化应激也是该领域的研究热点。多种微量元素与疾病的交叉研究可能是未来的发展趋势。
