University Department of Dermatology, Medical University of Vienna, Vienna, Austria.
J Dtsch Dermatol Ges. 2023 Nov;21(11):1369-1380. doi: 10.1111/ddg.15167. Epub 2023 Sep 18.
Extracorporeal photopheresis (ECP) has gained importance in the treatment of several diseases. Initially introduced as a new therapeutic modality for the treatment of patients with cutaneous T-cell lymphoma, the indications for the use of ECP have expanded to include hematology and transplantation immunology. Extracorporeal photopheresis has found its place in the treatment plan of cutaneous T-cell lymphoma, systemic sclerosis, graft-versus-host disease, organ transplantation such as heart and lung, sometimes as first-line therapy and very often in combination with various systemic immunosuppressive therapies. The procedure basically consists of three steps: leukapheresis, photoactivation and reinfusion. The following article presents possible theories about the mechanism of action, which is not yet fully understood, and discusses the five most common indications for ECP treatment with corresponding therapy recommendations.
体外光化学疗法（ECP）在治疗多种疾病方面的重要性日益增加。最初作为一种治疗皮肤 T 细胞淋巴瘤的新治疗方法引入，ECP 的适应证已扩展到血液学和移植免疫学。体外光化学疗法在皮肤 T 细胞淋巴瘤、系统性硬化症、移植物抗宿主病、心脏和肺等器官移植的治疗方案中找到了自己的位置，有时作为一线治疗，并且经常与各种全身性免疫抑制治疗联合应用。该过程主要包括三个步骤：白细胞分离术、光激活和再输注。本文提出了关于作用机制的可能理论，该机制尚未完全阐明，并讨论了 ECP 治疗的五个最常见适应证及其相应的治疗建议。
