P16免疫组化表达模式在浸润性导管癌女性患者中的预后意义
The Prognostic Significance of P16 Immunohistochemical Expression Pattern in Women with Invasive Ductal Breast Carcinoma.
作者信息
Rezaei Alireza, Shayan Navidreza, Shirazinia Saman, Mollazadeh Sara, Ghiyasi-Moghaddam Negin
机构信息
Department of Pathology, Faculty of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran.
出版信息
Rep Biochem Mol Biol. 2023 Apr;12(1):83-91. doi: 10.52547/rbmb.12.1.83.
BACKGROUND
Breast cancer is the most common malignancy in women worldwide. The p16 protein is a cell cycle regulator and tumor suppressor implicated in several types of cancers. However, its relationship to breast cancer is still unknown. The present study aimed to assess the association of p16 protein expression with clinicopathological features in breast cancer.This study aimed to investigate the anti-cancer effects of different gum extracts on metabolic changes and their impact on gene expression in HT-29 cell.
METHODS
The study enrolled 100 patients with invasive ductal carcinoma. The samples were collected before any adjuvant chemotherapy, and p16 protein expression was determined using immunohistochemistry. Clinicopathological features were obtained from the patient's medical records.
RESULTS
Our findings demonstrated that p16 protein expression increased in estrogen receptor-positive tumor tissues (P< 0.01). However, no significant correlation was found between the p16 protein expression and the other clinicopathological features.
CONCLUSIONS
Our study demonstrated that p16 protein expression increased in ER-positive tumor tissue from patients with invasive ductal breast carcinoma. However, no correlation was found between the p16 protein expression and the other clinicopathological features.
背景
乳腺癌是全球女性中最常见的恶性肿瘤。p16蛋白是一种细胞周期调节因子和肿瘤抑制因子，与多种类型的癌症有关。然而，其与乳腺癌的关系仍不清楚。本研究旨在评估p16蛋白表达与乳腺癌临床病理特征之间的关联。本研究旨在研究不同牙龈提取物对HT-29细胞代谢变化的抗癌作用及其对基因表达的影响。
方法
本研究纳入了100例浸润性导管癌患者。在进行任何辅助化疗之前收集样本，并使用免疫组织化学法测定p16蛋白表达。临床病理特征来自患者的病历。
结果
我们的研究结果表明，雌激素受体阳性肿瘤组织中p16蛋白表达增加（P<0.01）。然而，未发现p16蛋白表达与其他临床病理特征之间存在显著相关性。
结论
我们的研究表明，浸润性导管癌患者的雌激素受体阳性肿瘤组织中p16蛋白表达增加。然而，未发现p16蛋白表达与其他临床病理特征之间存在相关性。
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