p16 蛋白表达在乳腺癌中的预后意义。
Prognostic Significance of p16 Protein Expression in Breast Cancer.
机构信息
Department of Clinical Laboratory Science, College of Applied Medical Sciences, Taif University, Taif, Kingdom of Saudi Arabia;
Faculty of Medical Laboratory Science, Histopathology Department, Al Neelain University, Coralville, IA, U.S.A.
出版信息
In Vivo. 2022 Jan-Feb;36(1):336-340. doi: 10.21873/invivo.12707.
BACKGROUND/AIM: Breast cancer is the most common cancer in Sudan. The p16 protein plays a vital role in the regulation of the cell cycle.
PATIENTS AND METHODS
This study analysed the protein expression of p16 in 202 paraffin blocks from Sudanese women with breast cancer using immunohistochemistry.
RESULTS
This study included 168 (83.2%), 16 (7.9%), and 18 (8.9%) patients with invasive ductal carcinoma, invasive lobular carcinoma, and papillary carcinoma, respectively. There were 95 cases (47.0%) with grade III, 70 cases (34.6%) with grade II, and 23 cases (11.4%) with grade I breast cancer. The hormone receptor status was available for 119 of the cases, and 31 (15.3%), 25 (12.4%), and 63 (31.2%) cases were positive for oestrogen, progesterone, and HER2 receptors, respectively.
CONCLUSION
p16 protein expression was associated with high histologic grade, lymph node metastasis, and poor prognosis. p16 protein expression may potentially be used as a prognostic marker.
背景/目的：乳腺癌是苏丹最常见的癌症。p16 蛋白在细胞周期调控中起着至关重要的作用。
患者和方法
本研究使用免疫组织化学方法分析了 202 例苏丹乳腺癌石蜡块中 p16 蛋白的表达。
结果
本研究包括浸润性导管癌 168 例（83.2%）、浸润性小叶癌 16 例（7.9%）和乳头状癌 18 例（8.9%）。有 95 例（47.0%）为 III 级、70 例（34.6%）为 II 级和 23 例（11.4%）为 I 级乳腺癌。119 例有激素受体状态，雌激素、孕激素和 HER2 受体阳性的分别为 31 例（15.3%）、25 例（12.4%）和 63 例（31.2%）。
结论
p16 蛋白表达与高组织学分级、淋巴结转移和不良预后相关。p16 蛋白表达可能可作为一种预后标志物。
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