确定导致 SARS-CoV-2 相关蝙蝠冠状病毒对蝙蝠 ACE2 具有嗜性的因素。
Determination of the factors responsible for the tropism of SARS-CoV-2-related bat coronaviruses to bat ACE2.
机构信息
Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo , Tokyo, Japan.
Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
出版信息
J Virol. 2023 Oct 31;97(10):e0099023. doi: 10.1128/jvi.00990-23. Epub 2023 Sep 19.
The efficiency of infection receptor use is the first step in determining the species tropism of viruses. After the coronavirus disease 2019 pandemic, a number of SARS-CoV-2-related coronaviruses (SC2r-CoVs) were identified in bats, and some of them can use human angiotensin converting enzyme 2 (ACE2) for the infection receptor without acquiring additional mutations. This means that the potential of certain SC2r-CoVs to cause spillover from bats to humans is "off-the-shelf." However, both SC2r-CoVs and bat species are highly diversified, and the host tropism of SC2r-CoVs remains unclear. Here, we focus on two Laotian SC2r-CoVs, BANAL-20-236 and BANAL-20-52, and determine how the tropism of SC2r-CoVs to bat ACE2 is determined at the amino acid resolution level.
病毒感染受体利用效率是决定病毒物种嗜性的第一步。在 2019 年冠状病毒病（COVID-19）大流行之后，在蝙蝠中发现了多种与严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）相关的冠状病毒（SC2r-CoV），其中一些可通过无需获得额外突变即可利用人类血管紧张素转换酶 2（ACE2）作为感染受体。这意味着某些 SC2r-CoV 从蝙蝠传播到人类的潜力是“现成的”。然而，SC2r-CoV 和蝙蝠物种均高度多样化，SC2r-CoV 的宿主嗜性尚不清楚。在这里，我们重点关注两种老挝的 SC2r-CoV，BANAL-20-236 和 BANAL-20-52，并确定在氨基酸分辨率水平上 SC2r-CoV 对蝙蝠 ACE2 的嗜性是如何决定的。
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